Table 2.
Identification of B. microti proteins with reported immune responses in vivo1
| Gene ID | Description | Class2 | Ig Response1 | AA length | MW (kDa) | Orthologues in other piroplasmids and P. falciparum3 |
|---|---|---|---|---|---|---|
| BMR1_03g00785 | BmGPI12, BMN1 family, BMN1–9, BmSA1 orthologue | GPI | IgM/IgG | 328 | 35.4 | |
| BMR1_02g04275 | BmGPI10, BMN1 family, N1–21a orthologue | GPI | IgG | 304 | 34.4 | |
| BMR1_02g03140 | S1/P1 Nuclease | SEC | IgM/IgG | 373 | 42.8 | PF3D7_1411900 |
| BMR1_03g00947 | Conserved Plasmodium protein, unknown function | SEC | IgM/IgG | 438 | 48.7 | PF3D7_1324300 |
| BMR1_01G00985 | Conserved Plasmodium protein, unknown function | SEC | IgM/IgG | 1025 | 114.4 | PF3D7_0822900 |
| BMR1_02g04280 | BMN2 family, possible orthologue of N1-10-2 | TM | IgM | 519 | 60.9 | |
| BMR1_04g07535 | N1–15 protein, maltese-cross seroactive antigen | SEC | IgG | 2396 | 265.7 | |
| BMR1_03g04695 | Rhoptry neck protein 2 | IgM/IgG | 1483 | 165.7 | BBOV_I001630 TA19390 PF3D7_1452000 | |
| BMR1_03g00020 | BMN2 family | SEC | IgM | 474 | 55.4 | |
| BMR1_04g07556 | Uncharacterized protein | TM | IgM | 218 | 24.4 | |
| BMR1_04g05531 | MDN1, REA1, midasin | IgG | 4337 | 493.1 | BBOV_III002250 TA18495 PF3D7_1434500 |
1
As reported in Silva, J.C., et al. 2016. Sci. Rep. 6: 35284.
2
GPI, Glycosylphosphatidylinositol; SEC, secreted; TM, transmembrane.
3
BBOV, Babesia bovis T2Bo; TA, Theileria annulata Muguga; PF3D7, Plasmodium falciparum 3D7. B. bovis and T. annulata orthologues were found in PiroplasmaDB.org. P. falciparum orthologues were previously reported by Silva et al. (13).