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. 2023 Oct 4;131(10):107001. doi: 10.1289/EHP11538

Figure 1.

Figure 1 is a forest plot, plotting subgroup with stratification and cases, ranging (top to bottom) Median Age (in years), including Median age greater than 51 with 6,431 number of stratification and 1,348 cases, and Median age less than or equal to 51 with 6,809 number of stratification and 1,063 cases; Median body mass index (body mass index in kilograms per meter squared), including Median body mass index greater than or equal to 24 with 6,596 number of stratification and 1,315 cases and Median body mass index less than to 24 with 6,644 number of stratification and 1,096 cases; Dietary D A S H score, including Median D A S H score greater than 24 with 5,919 number of stratification and 1,043 cases and Median D A S H score less than or equal to 24 with 7,077 number of stratification and 1,331 cases; Smoking status, ever smokers with 6,304 number of stratification and 1,164 cases and Never smokers with 5,692 number of stratification and 1,056 cases; Parity, including Parous with 9,028 number of stratification and 1,675 cases and Nulliparous with 4,212 number of stratification and 736 cases; Percentage below federal poverty level in Neighborhood, including Median greater than 7.7 percent with 6,587 number of stratification and 1,153 cases and Median less than or equal to 7.7 percent with 6,653 number of stratification and 1,258 cases; Race or ethnicity, including non-Hispanic white with 9,115 number of stratification and 1,771 cases, non-Hispanic black with 1,370 number of stratification and 243 cases, Hispanic with 726 number of stratification and 98 cases; non-Hispanic other with 397 number of stratification and 59 cases; and Education level, including high school or less with 3,379 number of stratification and 632 cases, college or vocational school or other with 4,402 number of stratification and 778 cases, and graduate school with 3,061 number of stratification and 550 cases (y-axis) across hazard ratio, ranging from 0.5 to 1.5 in increments of 0.5 (x-axis) for hazard ratio (95 percent confidence intervals) and uppercase p for interaction.

HRs for obesity-related cancer risk based on neighborhood walkability by age, BMI, DASH score, smoking status, parity, poverty level, education level, and race/ethnicity. HRs and 95% CIs are shown for stratified survival models assessing the association between continuous neighborhood walkability (SD-scaled, SD=5.9) and obesity-related cancer risk by potential effect modifiers. Models were adjusted for all covariates (age, race/ethnicity, education level, smoking status, alcohol intake, menopausal status, parity, percentage below the poverty level living in neighborhood at baseline, and ever moving from baseline residence at any time during follow-up) except for the stratifying variable. Age was adjusted as a continuous variable in all models (including models stratified by median age). The x-axis in the forest plot shows the untransformed HRs on the log-scale. HR estimates are represented by the squares, bars represent the 95% CIs of the estimates, and the whiskers represent the lower and upper confidence limits. Obesity-related cancers include breast cancer diagnosed after menopause, colorectal (colon and rectal), pancreatic, endometrial (including uterine), ovarian, renal, thyroid, liver, gallbladder, and esophageal cancers, as well as meningioma, and multiple myeloma. pInteraction represents the p-value of the coefficient for the cross-product of continuous neighborhood walkability and the effect modifier. Interaction models were computed treating effect modifiers as dichotomized variables. All interactions had 13,240 observations except for analyses including dietary DASH score (n=12,996), smoking status (n=11,996), education level (n=10,842), and race/ethnicity (n=11,608), which were restricted to nonmissing values. Note: %, percentage; BMI, body mass index; CI, confidence interval; DASH, Dietary Approaches to Stop Hypertension; FPL, federal poverty level; HR, hazard ratio; NH, non-Hispanic.