Table 3.

Obesity-related cancer HRs and 95% CIs based on time-varying neighborhood walkability (NW) sensitivity analyses ($n=\mathrm{13,240}$).

	Cases ($n$)	NW HR (95% CI)
Overall (any first incident obesity-related cancer)	2,411	0.90 (0.86, 0.94)
Postmenopausal breast cancera	1,269	0.90 (0.85, 0.96)
Colorectal cancer	343	0.93 (0.92, 1.05)
Colon cancer	275	0.95 (0.82, 1.09)
Rectal cancer	68	0.85 (0.64, 1.14)
Cancer of the uterus (including endometrium)	282	0.88 (0.77, 1.00)
Ovarian cancer	138	0.84 (0.69, 1.02)
Pancreatic cancer	108	0.88 (0.70, 1.10)
Multiple myeloma and malignant plasma cell neoplasms	73	0.68 (0.49, 0.95)
Renal cancer	73	0.85 (0.63, 1.13)
Thyroid cancer	70	1.06 (0.82, 1.36)

Note: Time-varying Cox proportional hazard (PH) models were conducted to estimate the obesity-related cancer risk or HR associated with a per unit difference in continuous NW (SD-scaled), where $\text{SD}=5.9$. Annual walkability was considered for data points within the 31 y of follow-up. Models adjusted for covariates age, race/ethnicity, education level, smoking status, alcohol intake, menopausal status, parity, percentage below the poverty level living in neighborhood at baseline, and ever moving from baseline residence at any time during follow-up. Covariates alcohol, smoking status, education level, and race/ethnicity had missing observations and were included in the model using multiple imputation with 10 iterations for missing covariates. A total of 316,783.5 person-years at risk were accrued throughout the study. CI, confidence interval; HR, hazard ratio; SD, standard deviation.

^a Breast cancer diagnosed in menopause. Twenty-one women had unknown menopausal status at breast cancer diagnosis that were treated as a postmenopausal diagnosis if age at diagnosis was $>50$ and treated as premenopausal if age at diagnosis was $<50$ years of age.