Fig. 1. Families and structures of different Cys-rich cyclic peptides used as molecular frameworks for the design of novel antimicrobial peptides as described in the manuscript. These include α-defensins: Crp4 (PDB: 2GW9),158 β-defensins: hBD1 (PDB: 1IJV),160 hBD2 (PDB: 1FD3),161 hBD3 (PDB: 1KJ6)162 and RTD1 (PDB: 1HVZ);163 cathelicidins: PG-1 (PDB:1PG1)67 and LL-37 (pdb: 7PDC);164 Cys-rich backbone cyclized peptides: kalata B1 (pdb: 1NB1),99 cycloviolacin O2 (pdb: 1DF6)159 and SFTI-I (pdb: 4TTK);137 and β-hairpin peptides: gomesin (pdb: 1KFP)137 and thanatin (pdb: 5XO4). Their primary structures and antimicrobial properties are summarized in Table 1.
