Table 1:

Selected Interventional IHCA Trials from clinicaltrials.gov

Enrolling and Upcoming Interventional IHCA Trials

NCT03902873: The Effect of a Real-time Audiovisual Feedback System on CPR Quality Target Enrollment: 300, Recruiting Begin: 2018–11-20 End: 2021–11-20 Evaluate the effect of a real-time audiovisual feedback system on CPR quality during in-hospital cardiac arrest.

NCT04009759: Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival Target Enrollment: 240, Not yet recruiting Begin: 2021–10-01 (Anticipated) End: 2026–01-01 Evaluate the effect of morphine or/and ketamine on survival and neurological outcome in patients with cardiac arrest.

NCT05139849: VAsopressin and STeroids in Addition to Adrenaline in Cardiac Arrest - a Randomized Clinical Trial Target Enrollment: 1276, Recruiting Begin: 2021–11-17 End: 2027–04-30 This is an investigator initiated randomized, placebo controlled, double blind, superiority, multicenter clinical trial of patients with IHCA who are receiving epinephrine randomized to either treatment with vasopressin and steroids or placebo.

NCT04924985: Goal-directed CPR Using Cerebral Oximetry Target Enrollment: 150, Recruiting Begin: 2022–02-11 End: 2025–07-31 A single-center, randomized controlled pilot trial of adults with IHCA randomized to physiologic feedback CPR with cerebral oxygenation and end-tidal carbon dioxide physiological targets or standard CPR.

NCT04220619: RescueTEE for In-hospital Cardiac Arrest (ReTEECA Trial) Target Enrollment: 250, Not yet recruiting Begin: 2022–03-01 (Anticipated) End: 2024–12-01 Studying the utility and interventional outcomes of rescue transesophageal echocardiography (RescueTEE) to aid in diagnosis, change in management, and outcomes during CPR by using a point of care RescueTEE protocol in the evaluation of in-hospital cardiac arrest (IHCA).

NCT05444049: NEURESCUE Device as an Adjunct to In-Hospital Cardiac Arrest (ARISE) Target Enrollment: 10, Not yet recruiting Begin: 2022–07-31 (Anticipated) End: 2023–03-31 The objective of this study is to investigate the feasibility of an aortic balloon occlusion device designed to improve cerebral blood flow as an adjunct to Advanced Cardiac Life Support (ACLS) in adults with cardiac arrest.

NCT05480319: Prospective Deployment of a Cardiac Arrest Response System (EDICARS) in the Emergency Department Target Enrollment: 2010, Not yet recruiting Begin: 2022–08-01 (Anticipated) End: 2023–07-31 A cluster-randomized trial of using wearable sensors on high-risk patients to prevent ED-based IHCA.

NCT04464603: Impact of a mHealth Supportive Tool on Cardiopulmonary Resuscitation' Situational Awareness Target Enrollment: 36, Not yet recruiting Begin: 2022–12-01 (Anticipated) End: 2023–05-01 A prospective, single-center, randomized controlled trial in a tertiary pediatric emergency department evaluating the impact of a mHealth supportive tool compared to conventional communication methods on situational awareness, leadership, team communication effectiveness and performance during standardized, simulation-based, pediatric in-hospital cardiac arrest scenario using a high-fidelity manikin.

NCT05520762: Hospital Airway Resuscitation Trial Target Enrollment: 1060, Not yet recruiting Begin: 2022–12-31 (Anticipated) End: 2027–02-28 A cluster-randomized, pragmatic trial of advanced airway management with a strategy of first choice supraglottic airway vs. first choice endotracheal intubation during in-hospital cardiac arrest.

NCT05564130: Bicarbonate for In-Hospital Cardiac Arrest Target Enrollment: 778, Not yet recruiting Begin: 2023–02-01 (Anticipated) End: 2026–02-01 An investigator-initiated, multicenter, randomized, placebo-controlled, parallel group, double-blind, superiority trial of sodium bicarbonate during adult in-hospital cardiac arrest.