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. 2023 Jul 31;32(20):2966–2980. doi: 10.1093/hmg/ddad122

Figure 4.

Figure 4

ORF57 interactome. (A) Outline of proteomic approach using SH-SY5Y cells expressing GFP::TDP-43ΔNLS. (B) High-confidence ORF57-bound proteins observed under basal conditions and the GO-BP functional annotations terms associated with these enriched proteins. Functional annotation terms were determined using ShinyGO Version 0.76.3 (81) (C) High-confidence ORF57-bound proteins observed in presence of SA and the GO-BP functional annotations terms associated with these enriched proteins. Enriched proteins in basal and stress conditions were considered significant when they have a Log2 fold-change > 0.58 and an FDR adjusted P-value < 0.05.