Summary of findings 5. 10‐day cefadroxil versus 10‐day ampicillin for treating lower urinary tract infection in children.
10‐day cefadroxil versus 10‐day ampicillin for treating lower urinary tract infection in children | ||||||
Patient or population: children with lower urinary tract infection Settings: not stated Intervention: 10‐day cefadroxil Comparison: 10‐day ampicillin | ||||||
Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
Assumed risk | Corresponding risk | |||||
10‐day ampicillin | 10‐day cefadroxil | |||||
Persistent bacteriuria | Study population | RR 0.33 (0.01 to 7.62) | 32 (1 study) | ⊕⊝⊝⊝ very low1,2 | ||
62 per 1000 | 21 per 1000 (1 to 480) | |||||
Medium risk population | ||||||
63 per 1000 | 21 per 1000 (1 to 480) | |||||
Persistent symptoms | Study population | RR 0.33 (0.01 to 7.62) | 32 (1 study) | ⊕⊝⊝⊝ very low1,2 | ||
62 per 1000 | 21 per 1000 (1 to 480) | |||||
Medium risk population | ||||||
63 per 1000 | 21 per 1000 (1 to 480) | |||||
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio | ||||||
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. |
1 Randomisation method, allocation concealment and blinding not reported. 2 Very small numbers of patients (32) and CIs are very wide and cross 1