Summary of findings 6. Single‐dose fosfomycin versus single‐dose netilmicin for treating lower urinary tract infection in children.
Single‐dose fosfomycin versus single‐dose netilmicin for treating lower urinary tract infection in children | ||||||
Patient or population: children with lower urinary tract infection Settings: outpatients department Intervention: single‐dose fosfomycin Comparison: single‐dose netilmicin | ||||||
Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
Assumed risk | Corresponding risk | |||||
Single‐dose netilmicin | Single‐dose fosfomycin | |||||
Persistent bacteriuria | Study population | RR 3.15 (0.68 to 14.64) | 135 (1 study) | ⊕⊝⊝⊝ very low1,2 | ||
31 per 1000 | 98 per 1000 (21 to 454) | |||||
Medium risk population | ||||||
31 per 1000 | 98 per 1000 (21 to 454) | |||||
Recurrence | Study population | RR 0.63 (0.26 to 1.56) | 135 (1 study) | ⊕⊝⊝⊝ very low1,2 | ||
156 per 1000 | 98 per 1000 (41 to 243) | |||||
Medium risk population | ||||||
156 per 1000 | 98 per 1000 (41 to 243) | |||||
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; | ||||||
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. |
1 Randomisation method, allocation concealment and blinding not reported. 2 Number of patients is reasonably small (135) and CIs are very wide and crossed 1