Khan 1981.

Methods	Study design: Quasi‐RCT Study period: NS
Participants	Inclusion criteria Setting/recruitment: Jewish Hospital and Medical Centre of Brooklyn, State University of New York, Downstate Medical Centre Country: USA Children aged six months to 15 years with symptoms of cystitis (including frequency and dysuria without fever) and significant bacteriuria defined as > 105 cfu/mL in 2 consecutive clean catch urine samples. Mean age: 5.65 years Number: treatment group (27); control group (27) Sex (M/F): 4/50 Exclusion criteria Younger than 6 months, or older than 15 years; urinary tract malformations; abnormal SCr or BUN values.
Interventions	Treatment group 3‐day treatment Control group 10‐day treatment Antimicrobial agents were 'chosen at random' for both groups and included ampicillin, sulfisoxazole and cephalexin in conventional doses given orally 4 times/day.
Outcomes	Persistent bacteriuria (3‐7 days following treatment) Recurrence (> 2 months following treatment)
Notes	Source of funding: NS
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Alternation
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patients were analysed in groups to which they were assigned
Selective reporting (reporting bias)	Low risk	Planned outcomes were analysed. Data for re‐infection was presented across cystitis, pyelonephritis and asymptomatic bacteriuria and was not reported for cystitis alone.