Malaka‐Zafirui 1984.

Methods	Study design: parallel RCT Study period: NS
Participants	Inclusion criteria Setting/recruitment: NS Children aged 8 months to 11.1 years with significant bacteriuria defined as ≥ 105 cfu/mL of a single pathogen in 2 consecutive mid‐stream urine samples Number: treatment group (16); control group (16) Exclusion criteria Hypersensitivity to cephalosporins or penicillins; abnormal hepatic, renal function, or structural anomalies
Interventions	Treatment group Cefadroxil 25 mg/kg once daily for 10 days Control group Ampicillin 50 mg/kg/d in 4 divided doses for 10 days
Outcomes	Persistent bacteriuria (10 days following treatment) Persistent symptoms (10 days following treatment)
Notes	Children with pyelonephritis were also included in this study and were reported separately. Source of funding: NS
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patients were analysed in group to which they were assigned
Selective reporting (reporting bias)	Low risk	All planned outcomes were analysed