Figure 1.

CH at the time of treatment is very common among patients receiving CAR T-cell therapy. (A) Frequency of CH across the entire cohort (n = 110) as measured by the VAF using a cutoff of 1%. (B) Distribution of the number of mutations found in patients of total cohort. Quantity of mutations stratified by the size of the clone considering low VAF %1–5% and high VAF >5%. (C) Number of mutated patients (y-axis) according to gene information (x-axis) at differing VAF groups (VAF ≥1% and VAF ≥5%). CAR = chimeric antigen receptor; CH = clonal hematopoiesis; VAF = variant allele frequency.