TABLE 3.
Functional enrichment analysis of the entire working pipeline.
| Functional terms | Term id | Term description | Observed gene count | Background gene count | False discovery rate | Matching proteins in your network (labels) |
|---|---|---|---|---|---|---|
| KEGG pathways | hsa04670 | Leukocyte transendothelial migration | 20 | 109 | 3.53E-41 | CLDN11,CLDN16,CLDN17,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 |
| hsa04514 | Cell adhesion molecules | 20 | 137 | 1.20E-39 | CLDN11,CLDN16,CLDN17,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 | |
| hsa04530 | Tight junction | 20 | 156 | 9.04E-39 | CLDN11,CLDN16,CLDN17,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 | |
| hsa05160 | Hepatitis C | 20 | 156 | 9.04E-39 | CLDN11,CLDN16,CLDN17,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 | |
| hsa05130 | Pathogenic Escherichia coli infection | 20 | 187 | 1.65E-37 | CLDN11,CLDN16,CLDN17,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 | |
| Reactome pathways | HSA-420029 | Tight junction interactions | 20 | 30 | 7.63E-50 | CLDN11,CLDN16,CLDN17,CLDN12,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN9,CLDN4,CLDN23,CLDN2 |
| GENE ONTOLOGY Biological process | #term ID | term description | observed gene count | background gene count | false discovery rate | matching proteins in your network (labels) |
| GO:0016338 | Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules | 20 | 21 | 2.58E-51 | CLDN11,CLDN16,CLDN17,CLDN12,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN9,CLDN4,CLDN23,CLDN2 | |
| GO:0070830 | Bicellular tight junction assembly | 20 | 58 | 9.47E-45 | CLDN11,CLDN16,CLDN17,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 | |
| GO:0007155 | Cell adhesion | 21 | 925 | 1.99E-25 | CLDN11,CLDN16,CLDN17,CLDN12,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 | |
| GO:0016337 | cell-cell adhesion | 12 | 291 | 3.52E-19 | CLDN11,CLDN5,CLDN4,CLDN3,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16,CLDN2,CLDN1 | |
| GO:0022610 | biological adhesion | 12 | 712 | 1.75E-14 | CLDN11,CLDN5,CLDN4,CLDN3,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16,CLDN2,CLDN1 | |
| GO:0035633 | Maintenance of blood-brain barrier | 4 | 34 | 5.02E-05 | CLDN12,CLDN1,CLDN3,CLDN5 | |
| GO:1903348 | Positive regulation of bicellular tight junction assembly | 3 | 6 | 6.01E-05 | CLDN1,CLDN3,CLDN5 | |
| GO:1901890 | Positive regulation of cell junction assembly | 4 | 102 | 0.0028 | CLDN1,CLDN19,CLDN3,CLDN5 | |
| GO:0061041 | Regulation of wound healing | 4 | 140 | 0.0089 | CLDN1,CLDN19,CLDN3,CLDN4 | |
| GO:0048871 | Multicellular organismal homeostasis | 5 | 352 | 0.0175 | CLDN12,CLDN1,CLDN3,CLDN5,CLDN4 | |
| GO:0090303 | Positive regulation of wound healing | 3 | 59 | 0.0198 | CLDN1,CLDN3,CLDN4 | |
| GO:1905050 | Positive regulation of metallopeptidase activity | 2 | 9 | 0.0289 | CLDN3,CLDN4 | |
| GENE ONTOLOGY Cellular components | GO:0005923 | Bicellular tight junction | 21 | 122 | 4.95E-43 | CLDN11,CLDN16,CLDN17,CLDN12,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 |
| GO:0016327 | Apicolateral plasma membrane | 6 | 19 | 2.94E-11 | CLDN7,CLDN3,CLDN6,CLDN8,CLDN5,CLDN4 | |
| GO:0016021 | Integral component of membrane | 21 | 5181 | 1.67E-10 | CLDN11,CLDN16,CLDN17,CLDN12,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 | |
| GO:0005886 | Plasma membrane | 21 | 5314 | 2.52E-10 | CLDN11,CLDN16,CLDN17,CLDN12,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 | |
| GO:0016328 | Lateral plasma membrane | 6 | 61 | 9.40E-09 | CLDN12,CLDN1,CLDN7,CLDN3,CLDN15,CLDN4 | |
| GO:0016323 | Basolateral plasma membrane | 5 | 237 | 0.00058 | CLDN1,CLDN19,CLDN7,CLDN8,CLDN4 | |
| GO:0070160 | Occluding junction | 12 | 74 | 2.55E-25 | CLDN11,CLDN5,CLDN4,CLDN3,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16,CLDN2,CLDN1 | |
| GO:0043296 | Apical junction complex | 12 | 85 | 1.02E-24 | CLDN11,CLDN5,CLDN4,CLDN3,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16,CLDN2,CLDN1 | |
| GO:0005911 | Cell-cell junction | 12 | 192 | 1.68E-20 | CLDN11,CLDN5,CLDN4,CLDN3,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16,CLDN2,CLDN1 | |
| GO:0030054 | Cell junction | 12 | 522 | 2.70E-15 | CLDN11,CLDN5,CLDN4,CLDN3,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16,CLDN2,CLDN1 | |
| GO:0044459 | Plasma membrane part | 13 | 1999 | 6.09E-10 | CLDN2,CLDN1,CLDN11,CLDN5,CLDN4,CLDN3,RAB25,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16 | |
| GO:0044425 | Membrane part | 13 | 6114 | 5.42E-04 | CLDN2,CLDN1,CLDN11,CLDN5,CLDN4,CLDN3,RAB25,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16 | |
| GO:0016021 | Integral to membrane | 12 | 5266 | 7.70E-04 | CLDN11,CLDN5,CLDN4,CLDN3,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16,CLDN2,CLDN1 | |
| GO:0031224 | Intrinsic to membrane | 12 | 5375 | 8.72E-04 | CLDN11,CLDN5,CLDN4,CLDN3,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16,CLDN2,CLDN1 | |
| GO:0016020 | Membrane | 13 | 7253 | 2.82E-03 | CLDN2,CLDN1,CLDN11,CLDN5,CLDN4,CLDN3,RAB25,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,CLDN16 | |
| GO:0098590 | Plasma membrane region | 8 | 1219 | 0.0026 | CLDN1,CLDN19,CLDN7,CLDN3,CLDN6,CLDN8,CLDN5,CLDN4 | |
| GENE ONTOLOGY Molecular functions | GO:0005198 | Structural molecule activity | 20 | 635 | 1.52E-25 | CLDN11,CLDN16,CLDN17,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN25,CLDN9,CLDN4,CLDN23,CLDN2 |
| GO:0042802 | Identical protein binding | 20 | 1896 | 1.81E-16 | CLDN11,CLDN16,CLDN17,CLDN12,CLDN1,CLDN19,CLDN10,CLDN22,CLDN7,CLDN20,CLDN3,CLDN6,CLDN14,CLDN8,CLDN15,CLDN5,CLDN9,CLDN4,CLDN23,CLDN2 | |
| GO:0005515 | Protein binding | 15 | 8123 | 7.99E-04 | KLHL3,CLDN2,CLDN1,CLDN11,CLDN5,CLDN4,CLDN3,RAB25,CLDN14,CLDN8,CLDN23,CLDN7,CLDN12,SNAI1,CLDN16 |