TABLE 4.
Relationship between mutations in GyrA and ParC and the pazufloxacin MIC for N. gonorrhoeae
| Mutation
|
No. of strains | Mean MIC (μg/ml)
|
|||
|---|---|---|---|---|---|
| GyrA | ParC | Pazufloxacin | Norfloxacin | Ciprofloxacin | |
| Wild type | Wild type | 15 | 0.013 | 0.032 | 0.0069 |
| Ala75Ser | Wild type | 5 | 0.08 (6×)a | 0.14 (4×) | 0.019 (3×) |
| Ser91Phe | Wild type | 14 | 0.86 (66×) | 1.72 (54×) | 0.28 (41×) |
| Asp95Asn | Wild type | 2 | 0.2 (15×) | 0.59 (18×) | 0.075 (11×) |
| Asp95Gly | Wild type | 2 | 0.075 (6×) | 0.3 (9×) | 0.038 (6×) |
| Ser91Phe and Asp95Gly | Wild type | 1 | 3.13 (240×) | 3.13 (98×) | 0.39 (57×) |
| Ser91Phe and Asp95Gly | Glu91Gly | 1 | 3.13 (240×) | 12.5 (390×) | 3.13 (454×) |
| Ser91Phe and Asp95Asn | Ser88Pro | 1 | 12.5 (961×) | 12.5 (390×) | 3.13 (454×) |
a
The values in parentheses refer to the increase in the MIC compared with the MICs for the wild-type isolates.