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. 2023 Oct 4;18(10):e0291923. doi: 10.1371/journal.pone.0291923

Table 1. Summary of CGM metrics by presence of prediabetes in healthy non-diabetes participants (n = 40).

Characteristics of research participants Healthy (n = 26) Prediabetes (n = 14) P
Male (%) 12 (46%) 8 (57%) 0.507
Age, year (range) 33.9 ± 9.2 (23∼56) 52.3 ± 5.2 (45∼60) 0.000
BMI, kg/m2 (range) 21.1 ± 2.8 (16.9∼28) 21.5 ± 2.1 (18.5∼25.1) 0.660
FBS, mg/dL (range) 84.2 ± 6.9 (67∼97) 101.9 ± 9.2 (84∼117) 0.000
HbA1c, % (range) 5.0 ± 0.2 (4.4∼5.5) 5.6 ± 0.3 (5.0∼6.1) 0.000
Overall glucose distribution and variability
Mean, mg/dL 104.1 ± 20.7 110.0 ± 8.7 0.316
SD, mg/dL 20.0 ± 4.1 22.1 ± 4.4 0.151
CV, % 18.2 ± 3.9 20.1 ± 3.7 0.163
MAGE, mg/dL 49.2 ± 9.4 56.0 ± 11.4 0.044
Percentage of glucose sensor values
TAR (180), % 0.9 ± 1.3 1.6 ± 1.5 0.086
TAR (180) ≻ 0, % 13 (50%) 10 (71%) 0.191
TIR (70–180), % 97.6 ± 2.8 97.8 ± 1.3 0.832
TAR (140), % 8.0 ± 7.1 10.6 ± 6.2 0.253
TIR (70–140), % 90.5 ± 7.2 88.6 ± 5.9 0.407
Total energy, nutrients, food groups
Energy, kcal/d 1482 ± 380 1814 ± 587 0.037
Carbohydrate, % energy 48.3 ± 6.9 46.9 ± 7.7 0.556
Alcohol, % energy 6.4 ± 7.0 5.0 ± 8.0 0.570
Confections, g/d 59.2 ± 45.7 62.5 ± 40.7 0.823
Sugar sweetened beverages, g/d 55.7 ± 73.8 97.1 ± 101.7 0.193
Lifestyle behaviors
G5: Do you eat fast? 2.9 ± 0.8 2.8 ± 01.0 0.645
G6: Do you often eat snacks? 2.2 ± 0.9 1.9 ± 0.9 0.313
G6: Do you often drink? 2.2 ± 0.9 1.9 ± 0.9 0.313
G7: Do you often skip breakfast? 2.1 ± 1.1 1.6 ± 1.2 0.237
G7: Do you eat between meals during the day? 2.6 ± 0.9 1.9 ± 0.8 0.023
G7: Do you eat a late-night snack? 2.0 ± 0.9 1.3 ± 0.5 0.011
Dairy activity (n = 25, 14)
Average dairy step counts 9172 ± 2056 9446 ± 3495 0.797

CGM, continuous glucose monitoring; SD, standard deviation; CV, coefficient variation; MAGE, mean amplitude of glycemic excursions; TAR, time above range; TIR, time in range. Prediabetes was defined by the HbA1c level of 5.7 to 6.4% and /or impaired fasting glucose level of 100 to 125 mg/dL.