Table 14.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for Children and Adolescents (Ages 0-19 Years) by Histopathology and Sex, CBTRUS Statistical Report: US Cancer Statistics – NPCR and SEER, 2016-2020
| Histopathology | Total | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 1,907 | 381 | 0.47 (0.45-0.49) | 1,041 | 208 | 0.50 (0.47-0.53) | 866 | 173 | 0.43 (0.41-0.46) |
| Diffuse astrocytoma | 808 | 162 | 0.20 (0.18-0.21) | 424 | 85 | 0.20 (0.18-0.22) | 384 | 77 | 0.19 (0.17-0.21) |
| Anaplastic astrocytoma | 298 | 60 | 0.07 (0.07-0.08) | 169 | 34 | 0.08 (0.07-0.09) | 129 | 26 | 0.06 (0.05-0.08) |
| Glioblastoma | 642 | 128 | 0.16 (0.15-0.17) | 366 | 73 | 0.18 (0.16-0.19) | 276 | 55 | 0.14 (0.12-0.16) |
| Oligodendroglioma | 125 | 25 | 0.03 (0.03-0.04) | 62 | 12 | 0.03 (0.02-0.04) | 63 | 13 | 0.03 (0.02-0.04) |
| Anaplastic oligodendroglioma | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Oligoastrocytic tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Astrocytic Tumors | 4,456 | 891 | 1.10 (1.07-1.13) | 2,383 | 477 | 1.15 (1.10-1.20) | 2,073 | 415 | 1.04 (1.00-1.09) |
| Pilocytic astrocytoma | 3,963 | 793 | 0.98 (0.95-1.01) | 2,117 | 423 | 1.02 (0.98-1.06) | 1,846 | 369 | 0.93 (0.89-0.97) |
| Unique astrocytoma variants | 493 | 99 | 0.12 (0.11-0.13) | 266 | 53 | 0.13 (0.11-0.15) | 227 | 45 | 0.11 (0.10-0.13) |
| Malignant | 215 | 43 | 0.05 (0.05-0.06) | 104 | 21 | 0.05 (0.04-0.06) | 111 | 22 | 0.06 (0.05-0.07) |
| Non-Malignant | 278 | 56 | 0.07 (0.06-0.08) | 162 | 32 | 0.08 (0.07-0.09) | 116 | 23 | 0.06 (0.05-0.07) |
| Ependymal Tumors | 1,151 | 230 | 0.28 (0.27-0.30) | 663 | 133 | 0.32 (0.30-0.34) | 488 | 98 | 0.24 (0.22-0.27) |
| Malignant | 926 | 185 | 0.23 (0.21-0.24) | 526 | 105 | 0.25 (0.23-0.28) | 400 | 80 | 0.20 (0.18-0.22) |
| Non-Malignant | 225 | 45 | 0.05 (0.05-0.06) | 137 | 27 | 0.07 (0.05-0.08) | 88 | 18 | 0.04 (0.04-0.05) |
| Other Gliomas | 3,193 | 639 | 0.79 (0.76-0.82) | 1,549 | 310 | 0.75 (0.71-0.79) | 1,644 | 329 | 0.83 (0.79-0.87) |
| Glioma malignant, NOS | 3,167 | 633 | 0.78 (0.75-0.81) | -- | -- | -- | -- | -- | -- |
| Other neuroepithelial tumors | 26 | 5 | 0.01 (0.00-0.01) | -- | -- | -- | -- | -- | -- |
| Neuronal and Mixed Neuronal-Glial Tumors | 2,087 | 417 | 0.51 (0.49-0.53) | 1,178 | 236 | 0.57 (0.53-0.60) | 909 | 182 | 0.46 (0.43-0.49) |
| Malignant | 123 | 25 | 0.03 (0.03-0.04) | 59 | 12 | 0.03 (0.02-0.04) | 64 | 13 | 0.03 (0.02-0.04) |
| Non-Malignant | 1,964 | 393 | 0.48 (0.46-0.50) | 1,119 | 224 | 0.54 (0.51-0.57) | 845 | 169 | 0.42 (0.40-0.45) |
| Choroid Plexus Tumors | 395 | 79 | 0.10 (0.09-0.11) | 223 | 45 | 0.11 (0.09-0.12) | 172 | 34 | 0.09 (0.07-0.10) |
| Malignant | 94 | 19 | 0.02 (0.02-0.03) | 55 | 11 | 0.03 (0.02-0.03) | 39 | 8 | 0.02 (0.01-0.03) |
| Non-Malignant | 301 | 60 | 0.07 (0.07-0.08) | 168 | 34 | 0.08 (0.07-0.09) | 133 | 27 | 0.07 (0.06-0.08) |
| Tumors of The Pineal Region | 206 | 41 | 0.05 (0.04-0.06) | 103 | 21 | 0.05 (0.04-0.06) | 103 | 21 | 0.05 (0.04-0.06) |
| Malignant | 172 | 34 | 0.04 (0.04-0.05) | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 34 | 7 | 0.01 (0.01-0.01) | -- | -- | -- | -- | -- | -- |
| Embryonal Tumors | 2,266 | 453 | 0.56 (0.54-0.58) | 1,341 | 268 | 0.65 (0.61-0.68) | 925 | 185 | 0.47 (0.44-0.50) |
| Medulloblastoma | 1,590 | 318 | 0.39 (0.37-0.41) | 1,007 | 201 | 0.49 (0.46-0.52) | 583 | 117 | 0.29 (0.27-0.32) |
| Atypical teratoid/rhabdoid tumor | 356 | 71 | 0.09 (0.08-0.10) | 182 | 36 | 0.09 (0.08-0.10) | 174 | 35 | 0.09 (0.08-0.10) |
| All other embryonal | 320 | 64 | 0.08 (0.07-0.09) | 152 | 30 | 0.07 (0.06-0.09) | 168 | 34 | 0.08 (0.07-0.10) |
| Tumors of Cranial and Spinal Nerves | 1,031 | 206 | 0.25 (0.24-0.27) | 547 | 109 | 0.26 (0.24-0.28) | 484 | 97 | 0.24 (0.22-0.26) |
| Nerve sheath tumors | -- | -- | -- | 547 | 109 | 0.26 (0.24-0.28) | -- | -- | -- |
| Other tumors of cranial and spinal nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 1,250 | 250 | 0.31 (0.29-0.32) | 618 | 124 | 0.30 (0.27-0.32) | 632 | 126 | 0.32 (0.29-0.34) |
| Meningiomas | 667 | 133 | 0.16 (0.15-0.18) | 321 | 64 | 0.15 (0.14-0.17) | 346 | 69 | 0.17 (0.15-0.19) |
| Malignant | 19 | 4 | < 0.01 | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 648 | 130 | 0.16 (0.15-0.17) | -- | -- | -- | -- | -- | -- |
| Mesenchymal tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Primary melanocytic lesions | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Lymphomas and Hematopoietic Neoplasms | 122 | 24 | 0.03 (0.02-0.04) | 68 | 14 | 0.03 (0.03-0.04) | 54 | 11 | 0.03 (0.02-0.04) |
| Lymphoma | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other hematopoietic neoplasms | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Germ Cell Tumors | 848 | 170 | 0.21 (0.19-0.22) | 576 | 115 | 0.28 (0.25-0.30) | 272 | 54 | 0.14 (0.12-0.16) |
| Malignant | 760 | 152 | 0.19 (0.17-0.20) | 522 | 104 | 0.25 (0.23-0.27) | 238 | 48 | 0.12 (0.11-0.14) |
| Non-Malignant | 88 | 18 | 0.02 (0.02-0.03) | 54 | 11 | 0.03 (0.02-0.03) | 34 | 7 | 0.02 (0.01-0.02) |
| Tumors of Sellar Region | 4,635 | 927 | 1.13 (1.09-1.16) | 1,416 | 283 | 0.68 (0.64-0.71) | 3,219 | 644 | 1.59 (1.54-1.65) |
| Tumors of the pituitary | 3,872 | 774 | 0.94 (0.91-0.97) | 1,003 | 201 | 0.48 (0.45-0.51) | 2,869 | 574 | 1.42 (1.37-1.47) |
| Craniopharyngioma | 763 | 153 | 0.19 (0.18-0.20) | 413 | 83 | 0.20 (0.18-0.22) | 350 | 70 | 0.18 (0.16-0.20) |
| Unclassified Tumors | 1,452 | 290 | 0.36 (0.34-0.38) | 774 | 155 | 0.37 (0.35-0.40) | 678 | 136 | 0.34 (0.31-0.37) |
| Hemangioma | 485 | 97 | 0.12 (0.11-0.13) | 263 | 53 | 0.13 (0.11-0.14) | 222 | 44 | 0.11 (0.10-0.13) |
| Neoplasm, unspecified | 784 | 157 | 0.19 (0.18-0.21) | 413 | 83 | 0.20 (0.18-0.22) | 371 | 74 | 0.19 (0.17-0.21) |
| Malignant | 225 | 45 | 0.06 (0.05-0.06) | 117 | 23 | 0.06 (0.05-0.07) | 108 | 22 | 0.05 (0.04-0.07) |
| Non-Malignant | 559 | 112 | 0.14 (0.13-0.15) | 296 | 59 | 0.14 (0.13-0.16) | 263 | 53 | 0.13 (0.12-0.15) |
| All other | 183 | 37 | 0.05 (0.04-0.05) | 98 | 20 | 0.05 (0.04-0.06) | 85 | 17 | 0.04 (0.03-0.05) |
| Malignant | 45 | 9 | 0.01 (0.01-0.01) | 22 | 4 | 0.01 (0.01-0.02) | 23 | 5 | 0.01 (0.01-0.02) |
| Non-Malignant | 138 | 28 | 0.03 (0.03-0.04) | 76 | 15 | 0.04 (0.03-0.05) | 62 | 12 | 0.03 (0.02-0.04) |
| TOTAL c | 24,999 | 5,000 | 6.13 (6.06-6.21) | 12,480 | 2,496 | 6.00 (5.90-6.11) | 12,519 | 2,504 | 6.27 (6.16-6.38) |
| Malignant | 13,888 | 2,778 | 3.42 (3.36-3.48) | 7,554 | 1,511 | 3.64 (3.56-3.72) | 6,334 | 1,268 | 3.19 (3.11-3.27) |
| Non-Malignant | 11,111 | 2,222 | 2.71 (2.66-2.76) | 4,926 | 985 | 2.36 (2.30-2.43) | 6,185 | 1,237 | 3.08 (3.00-3.16) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
c Refers to all brain tumors including histopathologies not presented in this table.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified