Table 18.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for Children and Adolescents (Ages 0-19 Years) by Histopathology and Ethnicityc, CBTRUS Statistical Report: US Cancer Statistics – NPCR and SEER, 2016-2020
| Histopathology | Non-Hispanic | All Hispanic | White Hispanic | Black Hispanic | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 1,566 | 313 | 0.51 (0.49-0.54) | 339 | 68 | 0.33 (0.30-0.37) | 296 | 59 | 0.33 (0.30-0.37) | -- | -- | -- |
| Diffuse astrocytoma | 673 | 135 | 0.22 (0.20-0.24) | 134 | 27 | 0.13 (0.11-0.16) | 111 | 22 | 0.13 (0.10-0.15) | -- | -- | -- |
| Anaplastic astrocytoma | 247 | 49 | 0.08 (0.07-0.09) | 50 | 10 | 0.05 (0.04-0.07) | 43 | 9 | 0.05 (0.04-0.07) | -- | -- | -- |
| Glioblastoma | 510 | 102 | 0.17 (0.15-0.18) | 132 | 26 | 0.13 (0.11-0.15) | 120 | 24 | 0.14 (0.11-0.16) | -- | -- | -- |
| Oligodendroglioma | 110 | 22 | 0.04 (0.03-0.04) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Anaplastic oligodendroglioma | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Oligoastrocytic tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other Astrocytic Tumors | 3,639 | 728 | 1.20 (1.16-1.24) | 811 | 162 | 0.79 (0.74-0.85) | 712 | 142 | 0.80 (0.74-0.86) | 24 | 5 | 0.36 (0.23-0.53) |
| Pilocytic astrocytoma | 3,261 | 652 | 1.07 (1.04-1.11) | 697 | 139 | 0.68 (0.63-0.73) | 612 | 122 | 0.69 (0.63-0.74) | -- | -- | -- |
| Unique astrocytoma variants | 378 | 76 | 0.12 (0.11-0.14) | 114 | 23 | 0.11 (0.09-0.13) | 100 | 20 | 0.11 (0.09-0.14) | -- | -- | -- |
| Malignant | 167 | 33 | 0.05 (0.05-0.06) | 47 | 9 | 0.05 (0.03-0.06) | 41 | 8 | 0.05 (0.03-0.06) | -- | -- | -- |
| Non-Malignant | 211 | 42 | 0.07 (0.06-0.08) | 67 | 13 | 0.07 (0.05-0.08) | 59 | 12 | 0.07 (0.05-0.09) | -- | -- | -- |
| Ependymal Tumors | 893 | 179 | 0.29 (0.27-0.31) | 257 | 51 | 0.25 (0.22-0.28) | 228 | 46 | 0.26 (0.22-0.29) | -- | -- | -- |
| Malignant | 716 | 143 | 0.24 (0.22-0.25) | 209 | 42 | 0.20 (0.18-0.23) | 185 | 37 | 0.21 (0.18-0.24) | -- | -- | -- |
| Non-Malignant | 177 | 35 | 0.06 (0.05-0.07) | 48 | 10 | 0.05 (0.04-0.06) | 43 | 9 | 0.05 (0.04-0.07) | -- | -- | -- |
| Other Gliomas | 2,552 | 510 | 0.84 (0.81-0.87) | 634 | 127 | 0.62 (0.57-0.67) | 546 | 109 | 0.61 (0.56-0.67) | 29 | 6 | 0.40 (0.27-0.58) |
| Glioma malignant, NOS | 2,533 | 507 | 0.84 (0.80-0.87) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other neuroepithelial tumors | 19 | 4 | 0.01 (0.00-0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Neuronal and Mixed Neuronal-Glial Tumors | 1,699 | 340 | 0.55 (0.53-0.58) | 385 | 77 | 0.38 (0.34-0.42) | 334 | 67 | 0.38 (0.34-0.42) | -- | -- | -- |
| Malignant | 94 | 19 | 0.03 (0.02-0.04) | 29 | 6 | 0.03 (0.02-0.04) | 26 | 5 | 0.03 (0.02-0.04) | -- | -- | -- |
| Non-Malignant | 1,605 | 321 | 0.52 (0.50-0.55) | 356 | 71 | 0.35 (0.32-0.39) | 308 | 62 | 0.35 (0.31-0.39) | -- | -- | -- |
| Choroid Plexus Tumors | 305 | 61 | 0.10 (0.09-0.11) | 87 | 17 | 0.08 (0.07-0.10) | 76 | 15 | 0.09 (0.07-0.11) | -- | -- | -- |
| Malignant | 71 | 14 | 0.02 (0.02-0.03) | 23 | 5 | 0.02 (0.01-0.03) | 18 | 4 | 0.02 (0.01-0.03) | -- | -- | -- |
| Non-Malignant | 234 | 47 | 0.08 (0.07-0.09) | 64 | 13 | 0.06 (0.05-0.08) | 58 | 12 | 0.07 (0.05-0.09) | -- | -- | -- |
| Tumors of The Pineal Region | 165 | 33 | 0.05 (0.05-0.06) | 41 | 8 | 0.04 (0.03-0.05) | 36 | 7 | 0.04 (0.03-0.06) | -- | -- | -- |
| Malignant | 139 | 28 | 0.05 (0.04-0.05) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 26 | 5 | 0.01 (0.01-0.01) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Embryonal Tumors | 1,754 | 351 | 0.58 (0.55-0.61) | 500 | 100 | 0.49 (0.44-0.53) | 440 | 88 | 0.50 (0.45-0.54) | 24 | 5 | 0.34 (0.22-0.51) |
| Medulloblastoma | 1,224 | 245 | 0.41 (0.38-0.43) | 360 | 72 | 0.35 (0.32-0.39) | 317 | 63 | 0.36 (0.32-0.40) | -- | -- | -- |
| Atypical teratoid/rhabdoid tumor | 284 | 57 | 0.09 (0.08-0.11) | 71 | 14 | 0.07 (0.05-0.09) | 64 | 13 | 0.07 (0.06-0.09) | -- | -- | -- |
| All other embryonal | 246 | 49 | 0.08 (0.07-0.09) | 69 | 14 | 0.07 (0.05-0.08) | 59 | 12 | 0.07 (0.05-0.09) | -- | -- | -- |
| Tumors of Cranial and Spinal Nerves | 821 | 164 | 0.27 (0.25-0.28) | 209 | 42 | 0.21 (0.18-0.24) | 178 | 36 | 0.20 (0.17-0.23) | -- | -- | -- |
| Nerve sheath tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other tumors of cranial and spinal nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 958 | 192 | 0.31 (0.29-0.33) | 290 | 58 | 0.29 (0.26-0.32) | 259 | 52 | 0.29 (0.26-0.33) | -- | -- | -- |
| Meningiomas | 532 | 106 | 0.17 (0.16-0.19) | 134 | 27 | 0.13 (0.11-0.16) | 121 | 24 | 0.14 (0.11-0.16) | -- | -- | -- |
| Mesenchymal tumors | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 349 | 70 | 0.11 (0.10-0.13) | 132 | 26 | 0.13 (0.11-0.16) | -- | -- | -- | -- | -- | -- |
| Primary melanocytic lesions | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Lymphomas and Hematopoietic Neoplasms | 97 | 19 | 0.03 (0.03-0.04) | 24 | 5 | 0.02 (0.02-0.04) | 22 | 4 | 0.02 (0.02-0.04) | -- | -- | -- |
| Lymphoma | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other hematopoietic neoplasms | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Germ Cell Tumors | 631 | 126 | 0.21 (0.19-0.22) | 214 | 43 | 0.21 (0.18-0.24) | -- | -- | -- | -- | -- | -- |
| Malignant | 555 | 111 | 0.18 (0.17-0.20) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 76 | 15 | 0.03 (0.02-0.03) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Sellar Region | 3,366 | 673 | 1.08 (1.04-1.12) | 1,261 | 252 | 1.26 (1.20-1.34) | 1,106 | 221 | 1.25 (1.18-1.33) | 42 | 8 | 0.68 (0.49-0.92) |
| Tumors of the pituitary | 2,789 | 558 | 0.89 (0.86-0.92) | 1,076 | 215 | 1.08 (1.02-1.15) | 942 | 188 | 1.07 (1.00-1.14) | -- | -- | -- |
| Craniopharyngioma | 577 | 115 | 0.19 (0.18-0.21) | 185 | 37 | 0.18 (0.16-0.21) | 164 | 33 | 0.18 (0.16-0.21) | -- | -- | -- |
| Unclassified Tumors | 1,101 | 220 | 0.36 (0.34-0.38) | 349 | 70 | 0.34 (0.31-0.38) | 302 | 60 | 0.34 (0.30-0.38) | -- | -- | -- |
| Hemangioma | 365 | 73 | 0.12 (0.11-0.13) | 119 | 24 | 0.12 (0.10-0.14) | 104 | 21 | 0.12 (0.10-0.14) | -- | -- | -- |
| Neoplasm, unspecified | 606 | 121 | 0.20 (0.18-0.21) | 177 | 35 | 0.17 (0.15-0.20) | 151 | 30 | 0.17 (0.14-0.20) | -- | -- | -- |
| Malignant | 184 | 37 | 0.06 (0.05-0.07) | 41 | 8 | 0.04 (0.03-0.05) | 36 | 7 | 0.04 (0.03-0.06) | -- | -- | -- |
| Non-Malignant | 422 | 84 | 0.14 (0.12-0.15) | 136 | 27 | 0.13 (0.11-0.16) | 115 | 23 | 0.13 (0.11-0.16) | -- | -- | -- |
| All other | 130 | 26 | 0.04 (0.04-0.05) | 53 | 11 | 0.05 (0.04-0.07) | 47 | 9 | 0.05 (0.04-0.07) | -- | -- | -- |
| Malignant | 37 | 7 | 0.01 (0.01-0.02) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 93 | 19 | 0.03 (0.02-0.04) | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| TOTAL d | 19,547 | 3,909 | 6.38 (6.30-6.48) | 5,401 | 1,080 | 5.33 (5.18-5.47) | 4,729 | 946 | 5.33 (5.18-5.49) | 187 | 37 | 2.80 (2.41-3.24) |
| Malignant | 11,068 | 2,214 | 3.64 (3.57-3.71) | 2,788 | 558 | 2.73 (2.63-2.83) | 2,437 | 487 | 2.74 (2.63-2.85) | 110 | 22 | 1.57 (1.29-1.90) |
| Non-Malignant | 8,479 | 1,696 | 2.74 (2.69-2.80) | 2,613 | 522 | 2.60 (2.50-2.70) | 2,292 | 458 | 2.59 (2.49-2.70) | 77 | 15 | 1.23 (0.97-1.54) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cHispanic ethnicity is not mutually exclusive of race; Classified using the North American Association of Central Cancer Registries Hispanic Identification Algorithm, version 2 (NHIA v2).
d Refers to all brain tumors including histopathologies not presented in this table.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified.