Table 2.
Central Brain Tumor Registry of the United States (CBTRUS), 2021 Brain and Other Central Nervous System Tumor Histopathology Groupings (Based on 2016 WHO Classification)
| Histopathology | ICD-O-3a Histopathology Codesb | ICD-O-3a Histopathology and Behavior Codeb | |
|---|---|---|---|
| Malignant | Non-Malignant | ||
| Diffuse Astrocytic and Oligodendroglial Tumors | |||
| Diffuse astrocytoma* | 9381, 9400, 9410, 9411, 9420, 9442/1 | 9381/3, 9400/3, 9410/3, 9411/3, 9420/3 | 9442/1 |
| Anaplastic astrocytoma* | 9401 | 9401/3 | None |
| Glioblastoma* | 9440, 9441, 9442/3, 9445c | 9440/3, 9441/3, 9442/3, 9445/3 | None |
| Oligodendroglioma* | 9450 | 9450/3 | None |
| Anaplastic oligodendroglioma* | 9451, 9460 | 9451/3, 9460/3 | None |
| Oligoastrocytic tumors* | 9382 | 9382/3 | None |
| Other Astrocytic Tumors | |||
| Pilocytic astrocytoma* | 9421, 9425c | 9421/1d, 9425/3 | None |
| Unique astrocytoma variants* | 9384, 9424, 9431c | 9424/3 | 9384/1, 9431/1 |
| Ependymal Tumors* | 9383, 9391 (excluding site C75.1 for behavior/1), 9392- 9394, 9396c | 9391/3, 9392/3, 9393/3, 9396/3 | 9383/1, 9391/1 (excluding site C75.1), 9394/1 |
| Other Gliomas | |||
| Glioma malignant, NOS* | 9380, 9385c | 9380/3, 9385/3 | None |
| Other neuroepithelial tumors* | 9423, 9430, 9444 | 9423/3, 9430/3 | 9444/1 |
| Neuronal and Mixed Neuronal-Glial Tumors* | 8680, 8681, 8690, 8693, 9412, 9413, 9490, 9492 (excluding site C75.1), 9493, 9505, 9506, 9509c, 9522 (site C30.0 only), 9523 (site C30.0 only) | 8680/3, 8693/3, 9490/3, 9505/3, 9509/3, 9522/3 (site C30.0 only), 9523/3 (site C30.0 only) | 8680/0,1, 8681/1, 8690/1, 8693/1, 9412/1, 9413/0, 9442/1, 9490/0, 9492/0 (excluding site C75.1), 9493/0, 9505/0,1, 9506/1, 9509/1 |
| Choroid Plexus Tumors | 9390 | 9390/3 | 9390/0,1 |
| Tumors of The Pineal Region | 9360, 9361, 9362, 9395c | 9362/3, 9395/3 | 9360/1, 9361/1 |
| Embryonal Tumors | 8963, 9364, 9470-9478c, 9480, 9500, 9501/3, 9502/3, 9508 | 8963/3, 9364/3, 9470/3, 9471/3, 9472/3, 9473/3, 9474/3, 9475/3, 9476/3, 9477/3, 9478/3, 9480/3, 9500/3, 9501/3, 9502/3, 9508/3 | None |
| Medulloblastoma | 9470-9472,9474-9478 | 9470/3, 9471/3, 9472/3, 9474/3, 9475/3, 9476/3, 9477/3, 9478/3, | None |
| Atypical teratoid rhabdoid tumor | 9508 | 9508/3 | None |
| Other embryonal tumorse | 8963, 9364, 9473, 9480, 9500, 9501, 9502 | 8963/3, 9364/3, 9473/3, 9480/3, 9500/3, 9501/3, 9502/3 | None |
| Tumors of Cranial and Paraspinal Nerves | |||
| Nerve sheath tumors | 9540, 9541, 9550, 9560, 9561, 9570, 9571 | 9540/3, 9560/3, 9561/3, 9571/3 | 9540/0,1, 9541/0, 9550/0, 9560/0,1, 9570/0, 9571/0 |
| Other tumors of cranial and paraspinal nerves | 9562, 9563 | None | 9562/0, 9563/0 |
| Tumors of Meninges | |||
| Meningioma | 9530-9535, 9537-9539 | 9530/3, 9538/3, 9539/3 | 9530/0,1, 9531/0, 9532/0, 9533/0, 9534/0, 9535/0, 9537/0, 9538/1, 9539/1 |
| Mesenchymal tumors | 8324, 8710, 8711, 8800-8806, 8810, 8811, 8815, 8821, 8824, 8825, 8830, 8831, 8835, 8836, 8840, 8850-8854, 8857, 8861, 8870, 8880, 8890, 8897, 8900-8902, 8910, 8912, 8920, 8921, 8935, 8990, 9040, 9120, 9125, 9130, 9131, 9133, 9136, 9150, 9161, 9170, 9180, 9210, 9220, 9231, 9240, 9241, 9243, 9260, 9370-9373 | 8710/3, 8711/3, 8800/3, 8801/3, 8802/3, 8803/3, 8804/3, 8805/3, 8806/3, 8810/3, 8811/3, 8815/3c, 8825/3, 8830/3, 8840/3, 8850/3, 8851/3, 8852/3, 8853/3, 8854/3, 8857/3, 8890/3, 8900/3, 8901/3, 8902/3, 8910/3, 8912/3, 8920/3, 8921/3, 8935/3, 8990/3, 9040/3, 9120/3, 9130/3, 9150/3, 9170/3, 9180/3, 9220/3, 9231/3, 9240/3, 9243/3, 9260/3, 9370/3, 9371/3, 9372/3 | 8324/0, 8711/0, 8800/0, 8810/0, 8811/0, 8815/0,1c, 8821/1, 8824/0,1, 8825/0,1, 8830/0,1, 8831/0, 8835/1, 8836/1, 8840/0, 8850/0,1, 8851/0, 8852/0, 8854/0, 8857/0, 8861/0, 8870/0, 8880/0, 8890/0,1, 8897/1, 8900/0, 8920/1, 8935/0,1, 8990/0,1, 9040/0, 9120/0, 9125/0, 9130/0,1, 9131/0, 9136/1, 9150/0,1, 9161/0,1, 9170/0, 9180/0, 9210/0, 9220/0, 9241/0, 9373/0 |
| Primary melanocytic lesions | 8720, 8728, 8770 | 8720/3, 8728/3, 8770/3 | 8728/0,1, 8770/0 |
| Other neoplasms related to the meninges | None | None | None |
| Lymphomas and Hematopoietic Neoplasms | |||
| Lymphoma | 9590, 9591, 9596, 9650-9655, 9659, 9661-9665, 9667, 9670, 9671, 9673, 9675, 9680, 9684, 9687, 9688, 9690, 9691, 9695, 9698, 9699, 9701, 9702, 9705, 9712, 9714, 9715, 9719, 9724, 9727-9729, 9735, 9737, 9738, 9750, 9751, 9755, 9756, 9811-9819, 9823, 9826, 9827, 9831, 9832, 9837, 9861, 9866, 9930, 9965, 9966, 9967, 9970, 9971, 9975 | 9590/3, 9591/3, 9596/3, 9650/3, 9651/3, 9652/3, 9653/3, 9654/3, 9655/3, 9659/3, 9661/3, 9662/3, 9663/3, 9664/3, 9665/3, 9667/3, 9670/3, 9671/3, 9673/3, 9675/3, 9680/3, 9684/3, 9687/3, 9688/3, 9690/3, 9691/3, 9695/3, 9698/3, 9699/3, 9701/3, 9702/3, 9705/3, 9712/3, 9714/3, 9715/3, 9719/3, 9724/3, 9727/3, 9728/3, 9729/3, 9735/3, 9737/3, 9738/3, 9750/3, 9751/3, 9755/3, 9756/3, 9811/3, 9812/3, 9813/3, 9814/3, 9815/3, 9816/3, 9817/3, 9818/3, 9819/3, 9823/3, 9826/3, 9827/3, 9831/3, 9837/3, 9861/3, 9866/3, 9930/3, 9965/3, 9966/3, 9967/3, 9971/3, 9975/3 | 9750/1, 9751/1, 9766/1, 9970/1 |
| Other hematopoietic neoplasms | 9731, 9733, 9734, 9740, 9741, 9749, 9752-9754, 9757-9758, 9759, 9760, 9766, 9860, | 9731/3, 9733/3, 9734/3, 9740/3, 9741/3, 9749/3, 9753/3, 9754/3, 9756/3, 9757/3, 9758/3, 9759/3, 9760/3, 9766/3, 9823/3, 9826/3, 9827/3, 9832/3, 9860/3, | 9740/1, 9752/1, 9753/1, 9766/1 |
| Germ Cell Tumors | 8440, 9060, 9061, 9064, 9065, 9070-9072, 9080-9083, 9084/3, 9085, 9100, 9101 | 8440/3, 9060/3, 9061/3, 9064/3, 9065/3, 9070/3, 9071/3, 9072/3, 9080/3, 9081/3, 9082/3, 9083/3, 9084/3, 9085/3, 9100/3, 9101/3 | 8440/0, 9080/0,1 |
| Tumors of Sellar Region | |||
| Tumors of the pituitary | 8040 (site C75.1 only), 8140 (site C75.1 only), 8146 (site C75.1 only), 8246, 8260 (site C75.1 only), 8270-8272, 8280, 8281, 8290, 8300, 8310, 8323, 9391/1 (site C75.1 only), 9432c (site C75.1 only), 9492 (site C75.1 only), 9580, 9582 | 8140/3, 8246/3, 8260/3, 8270/3, 8272/3, 8280/3, 8281/3, 8290/3, 8300/3, 8310/3, 8323/3, 9580/3 | 8040/0,1, 8140/0,1, 8146/0, 8260/0, 8270/0, 8271/0, 8272/0, 8280/0, 8281/0, 8290/0, 8300/0, 8310/0, 8323/0, 9391/1 (site C75.1 only), 9432/1, 9492/0 (site C75.1 only), 9580/0, 9582/0 |
| Craniopharyngioma | 9350-9352 | None | 9350/1, 9351/1, 9352/1 |
| Unclassified Tumors | |||
| Hemangioma | 9121-9123, 9133, 9140 | 9133/3, 9140/3 | 9121/0, 9122/0, 9123/0, 9133/1 |
| Neoplasm, unspecified | 8000-8005, 8010, 8020, 8021 | 8000/3, 8001/3, 8002/3, 8003/3, 8004/3, 8005/3, 8010/3, 8020/3, 8021/3 | 8000/0,1, 8001/0,1, 8005/0, 8010/0 |
| All other | 8320, 8452, 8713, 8896, 8963, 8980, 9084/0, 9173, 9363, 9503 | 8320/3, 8452/3, 8896/3, 8980/3, 9503/3 | 8452/1, 8713/0, 9084/0, 9173/0, 9363/0 |
aInternational Classification of Diseases for Oncology, 3rd Edition, 2000. World Health Organization, Geneva, Switzerland.
bSee the CBTRUS website for additional information about the specific histopathology codes included in each group: http://www.cbtrus.org.
cAdded starting with diagnosis year 2018.
dThis histopathology is re-coded from behavior /1 to /3 and included in estimates for malignant brain and other central nervous system tumors by cancer surveillance organizations. Please see the following for more information: Ostrom QT, Kruchko C, Barnholtz-Sloan JS. Pilocytic astrocytomas: where do they belong in cancer reporting? Neuro Oncol. 2020;22(2):298-300. doi: 10.1093/neuonc/noz202.
e Includes tumors formerly classified as primitive neuroectodermal tumors of the central nervous system (PNET).
* All or some of this histopathology is included in the CBTRUS definition of gliomas, including ICD-O-3 histopathology codes 9380-9384, 9391-9460.
Abbreviations: WHO, World Health Organization; NOS, not otherwise specified.