Table 21.
Hazards Ratios with 95% Confidence Intervals for Age Group, Sex, Race, and Ethnicity for Primary Malignant Brain and Other Central Nervous System Tumor Histopathologies, CBTRUS Statistical Report: NPCR, 2001-2019 (varying)
| Histopathology | N | Deaths | Age Groupsa | Sexb | Race & Ethnicityc | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (15-39) Years | 40+ Years | Female | Black, Non-Hispanic | Hispanic | AIAN, Non-Hispanic | API, Non-Hispanic | ||||||||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |||
| Diffuse astrocytoma | 24,819 | 13,755 | 1.91 (1.74-2.10) | <0.0001 | 6.79 (6.21-7.42) | <0.0001 | 0.95 (0.92-0.99) | 0.0046 | 1.03 (0.96-1.09) | 0.4422 | 0.80 (0.75-0.84) | <0.0001 | 0.81 (0.65-1.00) | 0.0487 | 0.88 (0.79-0.98) | 0.0216 |
| Anaplastic astrocytoma | 17,735 | 12,514 | 0.39 (0.35-0.43) | <0.0001 | 1.27 (1.17-1.38) | <0.0001 | 0.96 (0.93-1.00) | 0.0407 | 1.08 (1.01-1.16) | 0.0220 | 0.82 (0.77-0.88) | <0.0001 | 0.94 (0.73-1.20) | 0.6044 | 0.83 (0.74-0.93) | 0.0011 |
| Glioblastoma | 146,320 | 131,036 | 0.72 (0.67-0.77) | <0.0001 | 1.75 (1.65-1.87) | <0.0001 | 1.02 (1.01-1.03) | 0.0003 | 0.92 (0.90-0.95) | <0.0001 | 0.77 (0.75-0.79) | <0.0001 | 1.00 (0.91-1.09) | 0.9572 | 0.69 (0.67-0.72) | <0.0001 |
| Oligodendroglioma | 11,926 | 3,780 | 3.53 (2.42-5.14) | <0.0001 | 7.80 (5.37-11.33) | <0.0001 | 0.86 (0.81-0.92) | <0.0001 | 1.30 (1.14-1.49) | 0.0001 | 0.76 (0.68-0.86) | <0.0001 | 1.16 (0.76-1.77) | 0.4807 | 0.74 (0.60-0.91) | 0.0044 |
| Anaplastic oligodendroglioma | 5,339 | 2,533 | 0.75 (0.50-1.13) | 0.1694 | 1.56 (1.04-2.34) | 0.0311 | 0.90 (0.83-0.97) | 0.0071 | 1.25 (1.06-1.46) | 0.0072 | 0.80 (0.70-0.92) | 0.0012 | 1.16 (0.71-1.90) | 0.5575 | 0.81 (0.66-0.99) | 0.0431 |
| Oligoastrocytic tumors | 6,617 | 3,504 | 1.75 (1.30-2.35) | 0.0002 | 3.65 (2.72-4.89) | <0.0001 | 0.90 (0.84-0.96) | 0.0016 | 1.37 (1.20-1.57) | <0.0001 | 0.85 (0.76-0.95) | 0.0061 | 1.21 (0.80-1.82) | 0.3633 | 0.90 (0.74-1.09) | 0.2609 |
| Pilocytic astrocytoma | 312 | < 50 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Unique astrocytoma variants | 2,484 | 422 | 2.36 (1.80-3.09) | <0.0001 | 8.83 (6.72-11.60) | <0.0001 | 0.79 (0.65-0.96) | 0.0153 | 0.96 (0.72-1.27) | 0.7553 | 0.87 (0.66-1.16) | 0.3545 | 1.59 (0.71-3.57) | 0.2616 | 1.12 (0.68-1.86) | 0.6520 |
| Ependymal tumors | 18,645 | 3,407 | 0.33 (0.29-0.37) | <0.0001 | 0.87 (0.80-0.95) | 0.0017 | 0.78 (0.73-0.84) | <0.0001 | 1.40 (1.25-1.57) | <0.0001 | 1.10 (1.00-1.22) | 0.0502 | 1.15 (0.77-1.74) | 0.4942 | 0.80 (0.63-1.01) | 0.0597 |
| Glioma malignant, NOS | 20,839 | 10,035 | 0.77 (0.72-0.83) | <0.0001 | 3.48 (3.32-3.65) | <0.0001 | 1.00 (0.96-1.04) | 0.9476 | 1.11 (1.04-1.18) | 0.0013 | 1.03 (0.97-1.09) | 0.3591 | 0.93 (0.70-1.23) | 0.6048 | 0.95 (0.85-1.06) | 0.3764 |
| Choroid plexus tumors | 2,285 | 358 | 0.56 (0.40-0.80) | 0.0013 | 2.56 (2.02-3.24) | <0.0001 | 0.87 (0.71-1.08) | 0.2084 | 1.71 (1.22-2.38) | 0.0016 | 0.98 (0.73-1.32) | 0.9026 | 1.08 (0.35-3.39) | 0.8887 | 1.14 (0.65-1.99) | 0.6532 |
| Other neuroepithelial tumors | 280 | 84 | 2.53 (0.82-7.80) | 0.1059 | 15.51 (5.54-43.43) | <0.0001 | 0.87 (0.55-1.38) | 0.5643 | 0.91 (0.44-1.88) | 0.8077 | 0.65 (0.32-1.34) | 0.2420 | ** (**-**) | ** | 0.91 (0.33-2.53) | 0.8568 |
| Neuronal and mixed neuronal-glial tumors | 12,725 | 1,619 | 1.44 (1.19-1.73) | 0.0001 | 6.26 (5.31-7.39) | <0.0001 | 0.80 (0.72-0.88) | <0.0001 | 1.43 (1.23-1.66) | <0.0001 | 1.17 (1.01-1.37) | 0.0399 | 2.01 (1.20-3.34) | 0.0075 | 1.03 (0.79-1.36) | 0.8209 |
| Tumors of the pineal region | 1,948 | 538 | 0.51 (0.40-0.64) | <0.0001 | 1.06 (0.85-1.31) | 0.6176 | 0.59 (0.50-0.70) | <0.0001 | 1.36 (1.09-1.69) | 0.0065 | 1.22 (0.96-1.55) | 0.1039 | 1.08 (0.45-2.62) | 0.8628 | 0.65 (0.33-1.26) | 0.1982 |
| Embryonal tumors | 10,595 | 4,204 | 0.83 (0.77-0.90) | <0.0001 | 1.94 (1.77-2.13) | <0.0001 | 1.01 (0.95-1.07) | 0.8149 | 1.21 (1.10-1.33) | <0.0001 | 0.96 (0.89-1.03) | 0.2636 | 0.64 (0.42-0.98) | 0.0412 | 1.01 (0.86-1.18) | 0.9495 |
| Medulloblastoma | 7,007 | 2,075 | 0.88 (0.79-0.97) | 0.0092 | 1.68 (1.45-1.94) | <0.0001 | 0.92 (0.84-1.01) | 0.0769 | 1.08 (0.94-1.25) | 0.2638 | 0.97 (0.88-1.08) | 0.6141 | 0.54 (0.29-1.00) | 0.0509 | 0.78 (0.61-1.00) | 0.0504 |
| Atypical teratoid/rhabdoid tumor | 1,129 | 726 | 0.80 (0.55-1.17) | 0.2529 | 0.90 (0.51-1.60) | 0.7251 | 0.95 (0.82-1.10) | 0.4820 | 1.31 (1.06-1.61) | 0.0122 | 1.09 (0.91-1.30) | 0.3666 | 0.78 (0.29-2.09) | 0.6216 | 1.50 (1.09-2.06) | 0.0124 |
| Other embryonal tumors | 2,459 | 1,403 | 1.34 (1.18-1.53) | <0.0001 | 2.51 (2.20-2.86) | <0.0001 | 0.92 (0.82-1.02) | 0.1005 | 1.22 (1.04-1.44) | 0.0125 | 0.90 (0.78-1.04) | 0.1633 | 0.98 (0.47-2.07) | 0.9632 | 1.07 (0.81-1.40) | 0.6461 |
| Nerve sheath tumors | 89,222 | 9,235 | 1.59 (1.21-2.09) | 0.0009 | 6.19 (4.78-8.01) | <0.0001 | 0.83 (0.80-0.86) | <0.0001 | 1.19 (1.10-1.30) | <0.0001 | 0.84 (0.77-0.91) | <0.0001 | 1.29 (0.99-1.67) | 0.0610 | 0.57 (0.51-0.65) | <0.0001 |
| Other tumors of cranial and spinal nerves | 69 | < 50 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Meningiomas | 398,870 | 114,855 | 0.77 (0.59-1.02) | 0.0670 | 5.64 (4.31-7.39) | <0.0001 | 0.69 (0.68-0.70) | <0.0001 | 1.01 (1.00-1.03) | 0.1330 | 0.72 (0.70-0.74) | <0.0001 | 0.82 (0.75-0.89) | <0.0001 | 0.64 (0.61-0.66) | <0.0001 |
| Mesenchymal tumors | 16,523 | 3,054 | 0.84 (0.67-1.06) | 0.1451 | 3.17 (2.58-3.88) | <0.0001 | 0.85 (0.79-0.91) | <0.0001 | 1.10 (0.98-1.24) | 0.1060 | 0.89 (0.80-1.00) | 0.0604 | 0.94 (0.64-1.37) | 0.7476 | 0.71 (0.56-0.89) | 0.0031 |
| Primary melanocytic lesions | 282 | 171 | 0.30 (0.16-0.55) | 0.0001 | 0.64 (0.38-1.07) | 0.0885 | 0.91 (0.67-1.25) | 0.5621 | 1.41 (0.76-2.62) | 0.2766 | 0.96 (0.60-1.55) | 0.8814 | -- | -- | 1.00 (0.32-3.16) | 0.9998 |
| Lymphoma | 20,028 | 13,624 | 3.89 (2.72-5.56) | <0.0001 | 7.50 (5.27-10.67) | <0.0001 | 0.93 (0.90-0.96) | <0.0001 | 1.15 (1.09-1.22) | <0.0001 | 0.90 (0.85-0.95) | 0.0002 | 1.02 (0.81-1.28) | 0.8880 | 0.80 (0.74-0.87) | <0.0001 |
| Other hematopoietic neoplasms | 196 | 96 | ** (**-**) | ** | ** (**-**) | ** | 1.15 (0.76-1.73) | 0.5091 | 0.73 (0.43-1.22) | 0.2282 | 0.59 (0.30-1.17) | 0.1304 | 1.90 (0.46-7.89) | 0.3797 | 1.65 (0.71-3.85) | 0.2434 |
| Germ cell tumor | 3,601 | 529 | 1.04 (0.86-1.25) | 0.7058 | 2.20 (1.65-2.94) | <0.0001 | 1.32 (1.09-1.59) | 0.0047 | 0.87 (0.63-1.20) | 0.3961 | 1.11 (0.90-1.37) | 0.3253 | 1.57 (0.59-4.22) | 0.3696 | 1.03 (0.76-1.41) | 0.8373 |
| Tumors of the pituitary | 179,087 | 22,448 | 2.13 (1.37-3.31) | 0.0008 | 21.59 (13.92-33.47) | <0.0001 | 0.74 (0.72-0.76) | <0.0001 | 1.13 (1.10-1.17) | <0.0001 | 0.71 (0.68-0.74) | <0.0001 | 0.97 (0.82-1.15) | 0.7058 | 0.63 (0.58-0.68) | <0.0001 |
| Craniopharyngioma | 7,997 | 1,724 | 1.92 (1.53-2.40) | <0.0001 | 6.50 (5.37-7.87) | <0.0001 | 0.86 (0.78-0.95) | 0.0019 | 1.69 (1.51-1.89) | <0.0001 | 1.05 (0.90-1.22) | 0.5478 | 1.68 (1.05-2.67) | 0.0302 | 0.61 (0.44-0.83) | 0.0017 |
| Hemangioma | 8,891 | 1,029 | 1.15 (0.66-2.01) | 0.6139 | 8.01 (4.81-13.36) | <0.0001 | 0.63 (0.55-0.71) | <0.0001 | 1.28 (1.06-1.56) | 0.0103 | 0.79 (0.65-0.96) | 0.0206 | ** (**-**) | ** | 0.63 (0.43-0.94) | 0.0226 |
| Neoplasm, unspecified | 29,036 | 16,254 | 0.79 (0.68-0.92) | 0.0019 | 5.90 (5.19-6.71) | <0.0001 | 0.94 (0.91-0.96) | <0.0001 | 0.74 (0.70-0.78) | <0.0001 | 0.66 (0.63-0.70) | <0.0001 | 0.76 (0.61-0.94) | 0.0130 | 0.80 (0.72-0.89) | <0.0001 |
| All other | 1,285 | 222 | 1.19 (0.61-2.33) | 0.6110 | 9.43 (5.56-16.01) | <0.0001 | 0.73 (0.56-0.96) | 0.0218 | 1.36 (0.92-2.02) | 0.1237 | 0.98 (0.67-1.44) | 0.9353 | 3.02 (0.74-12.24) | 0.1223 | 0.67 (0.25-1.80) | 0.4238 |
aReference group is children (<15 years old) as defined by the National Cancer Institute, see: http://www.cancer.gov/researchandfunding/snapshots/pediatric.
bReference group is males.
c Reference group is White Non-Hispanic.
** Cannot be calculated.
--Survival estimates are not presented when fewer than 100 cases were reported for the specific category.
Abbreviations: CBTRUS, Central Brain Tumor of the United States; NPCR, National program of Cancer Registries; HR, Hazard ratio; AIAN, American Indian/Alaska Native; API, Asian or Pacific Islander; CI, confidence interval; NOS, not otherwise specified.