Table 22.
One-, Five-, and Ten-Year Relative Survival Ratesa,b with 95% Confidence Intervals for Brain and Other Central Nervous System Tumors by Site and Behavior, CBTRUS Statistical Report: US Cancer Statistics—NPCR and SEER, 2001-2019 (varying)
| Site (ICD-O Topography Code) | All | Malignantc | Non-Malignantd | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | 1 Year RS (95% CI) | 5 Year Relative Survival (95% CI) | 10 Year Relative Survival (95% CI) | Ne | 1 Year Relative Survival (95% CI) | 5 Year Relative Survival (95% CI) | 10 Year Relative Survival (95% CI) | Nf | 1 Year Relative Survival (95% CI) | 5 Year Relative Survival (95% CI) | 10 Year Relative Survival (95% CI) | |
| Olfactory tumors of the nasal cavity (C30.0) g | 1,805 | 91.3 (89.8-92.6) | 81.1 (78.7-83.3) | 72.4 (68.9-75.5) | 1,807 | 92.3 (90.9-93.6) | 82.4 (80.1-84.5) | 73.4 (70.2-76.4) | -- | -- | -- | -- |
| Frontal, temporal, parietal, and occipital lobes of the brain | 192,387 | 60.0 (59.8-60.3) | 31.8 (31.6-32.1) | 26.5 (26.3-26.8) | 174,553 | 58.1 (57.8-58.3) | 27.5 (27.2-27.7) | 21.7 (21.4-21.9) | 19,631 | 90.9 (90.5-91.4) | 86.8 (86.2-87.4) | 83.4 (82.6-84.2) |
| Frontal lobe | 83,162 | 62.2 (61.9-62.6) | 37.0 (36.6-37.4) | 30.6 (30.2-31.0) | 75,991 | 61.4 (61.0-61.7) | 34.3 (33.9-34.7) | 27.2 (26.9-27.6) | 7,954 | 89.3 (88.5-90.0) | 84.1 (83.0-85.1) | 80.0 (78.5-81.3) |
| Temporal lobe | 61,389 | 60.9 (60.5-61.3) | 29.1 (28.7-29.5) | 24.5 (24.0-24.9) | 54,808 | 58.3 (57.9-58.7) | 23.2 (22.8-23.6) | 18.0 (17.6-18.4) | 6,791 | 93.9 (93.2-94.5) | 91.1 (90.2-91.9) | 89.2 (88.0-90.2) |
| Parietal lobe | 37,603 | 54.2 (53.7-54.7) | 25.3 (24.8-25.8) | 20.9 (20.4-21.4) | 35,004 | 51.6 (51.0-52.1) | 20.7 (20.3-21.2) | 16.2 (15.8-16.7) | 3,396 | 88.6 (87.3-89.7) | 83.9 (82.3-85.4) | 80.0 (77.8-82.0) |
| Occipital lobe | 10,233 | 58.4 (57.4-59.3) | 30.2 (29.2-31.2) | 26.2 (25.1-27.2) | 8,750 | 54.1 (53.0-55.2) | 22.1 (21.1-23.0) | 18.0 (17.1-19.0) | 1,490 | 91.6 (89.9-93.0) | 88.2 (85.9-90.2) | 83.2 (80.0-86.0) |
| Cerebrum | 18,037 | 58.1 (57.4-58.9) | 38.3 (37.5-39.0) | 34.4 (33.6-35.3) | 15,440 | 52.8 (52.0-53.6) | 29.8 (29.0-30.5) | 26.0 (25.2-26.8) | 3,249 | 89.3 (88.1-90.4) | 84.8 (83.2-86.3) | 80.6 (78.3-82.6) |
| Ventricle, NOS | 10,770 | 86.5 (85.8-87.2) | 79.1 (78.2-80.0) | 75.0 (73.9-76.0) | 5,006 | 77.0 (75.8-78.2) | 64.3 (62.9-65.7) | 59.5 (57.9-61.0) | 6,166 | 94.5 (93.8-95.0) | 91.5 (90.5-92.3) | 88.5 (87.1-89.7) |
| Cerebellum, NOS | 23,386 | 88.3 (87.9-88.8) | 79.1 (78.5-79.7) | 75.5 (74.8-76.2) | 15,552 | 85.7 (85.1-86.3) | 72.8 (72.0-73.5) | 68.1 (67.3-69.0) | 9,254 | 95.1 (94.5-95.5) | 92.3 (91.5-93.1) | 90.3 (89.1-91.4) |
| Brain stem | 16,072 | 77.2 (76.5-77.9) | 62.1 (61.2-62.9) | 57.2 (56.3-58.1) | 13,476 | 72.3 (71.5-73.0) | 53.2 (52.3-54.1) | 48.2 (47.3-49.2) | 3,937 | 92.6 (91.7-93.5) | 88.5 (87.2-89.7) | 84.7 (82.8-86.4) |
| Other Brain | 78,884 | 53.3 (52.9-53.6) | 34.8 (34.5-35.2) | 30.8 (30.4-31.2) | 66,786 | 46.9 (46.5-47.3) | 25.5 (25.2-25.9) | 21.5 (21.1-21.9) | 15,122 | 86.1 (85.5-86.6) | 80.7 (79.9-81.4) | 76.5 (75.4-77.5) |
| Overlapping lesion of brain | 33,581 | 45.7 (45.2-46.3) | 21.3 (20.8-21.8) | 17.1 (16.6-17.6) | 32,448 | 44.2 (43.7-44.8) | 18.5 (18.0-18.9) | 14.2 (13.8-14.7) | 2,218 | 83.3 (81.6-84.9) | 78.0 (75.8-80.0) | 73.2 (70.5-75.7) |
| Brain, NOS | 45,303 | 58.9 (58.5-59.4) | 44.9 (44.3-45.4) | 41.0 (40.4-41.5) | 34,338 | 49.4 (48.9-50.0) | 32.2 (31.6-32.7) | 28.4 (27.8-28.9) | 12,904 | 86.5 (85.9-87.2) | 81.1 (80.3-82.0) | 77.0 (75.9-78.1) |
| Spinal cord and cauda equina | 31,275 | 96.1 (95.8-96.3) | 93.0 (92.6-93.4) | 91.2 (90.6-91.8) | 9,903 | 89.8 (89.2-90.5) | 81.7 (80.8-82.6) | 77.9 (76.8-79.0) | 22,009 | 99.1 (98.8-99.2) | 98.5 (98.1-98.9) | 98.0 (97.2-98.5) |
| Spinal cord | 30,155 | 96.0 (95.8-96.3) | 92.9 (92.5-93.3) | 91.0 (90.3-91.6) | 9,674 | 89.8 (89.2-90.4) | 81.6 (80.7-82.5) | 77.7 (76.6-78.8) | 21,092 | 99.1 (98.9-99.3) | 98.6 (98.1-98.9) | 97.9 (97.1-98.5) |
| Cauda equina | 1,120 | 96.8 (95.3-97.8) | 94.6 (92.2-96.3) | 94.4 (91.8-96.2) | 229 | 90.8 (85.8-94.0) | 86.4 (79.8-91.0) | 85.4 (77.3-90.8) | 917 | 98.2 (96.8-99.0) | 97.3 (94.4-98.7) | 97.0 (93.9-98.6) |
| Cranial nerves | 74,090 | 99.3 (99.2-99.4) | 99.3 (99.2-99.4) | 99.3 (99.2-99.4) | 4,309 | 97.4 (96.8-97.9) | 94.3 (93.5-95.0) | 93.1 (92.0-94.0) | 70,185 | 99.5 (99.4-99.6) | 99.5 (99.4-99.6) | 99.5 (99.4-99.6) |
| Olfactory nerve | 100 | 94.7 (87.1-97.9) | 88.9 (77.2-94.8) | 85.7 (69.5-93.7) | 34 | 92.0 (74.7-97.6) | 76.0 (54.5-88.3) | 68.3 (44.4-83.6) | 69 | 96.4 (85.9-99.1) | 93.3 (77.4-98.2) | 93.3 (77.4-98.2) |
| Optic nerve | 4,385 | 98.5 (98.1-98.9) | 96.3 (95.6-97.0) | 95.5 (94.5-96.3) | 3,852 | 98.1 (97.6-98.5) | 95.7 (95.0-96.4) | 94.8 (93.9-95.6) | 897 | 100.0 (**-**) | 98.4 (94.2-99.5) | 96.9 (91.4-98.9) |
| Acoustic nerve | 56,707 | 99.5 (99.4-99.6) | 99.5 (99.4-99.6) | 99.5 (99.4-99.6) | 146 | 95.0 (89.0-97.7) | 93.2 (86.3-96.7) | 93.1 (81.6-97.5) | 56,597 | 99.5 (99.4-99.6) | 99.5 (99.4-99.6) | 99.5 (99.4-99.6) |
| Cranial nerve, NOS | 12,898 | 98.9 (98.6-99.2) | 98.8 (98.4-99.1) | 98.8 (98.4-99.1) | 277 | 89.0 (84.3-92.3) | 76.0 (69.7-81.2) | 70.7 (62.5-77.4) | 12,622 | 99.2 (99.0-99.5) | 99.2 (98.8-99.5) | 99.2 (98.8-99.5) |
| Other nervous system | 6,208 | 79.8 (78.8-80.9) | 72.2 (70.9-73.5) | 67.8 (66.2-69.4) | 3,101 | 63.8 (62.0-65.5) | 50.5 (48.5-52.5) | 44.7 (42.3-47.0) | 3,043 | 97.3 (96.5-97.9) | 94.6 (93.3-95.6) | 91.8 (89.8-93.3) |
| Overlapping lesion of brain & CNS | 806 | 75.1 (71.8-78.0) | 66.4 (62.5-70.0) | 61.1 (56.2-65.7) | 453 | 61.7 (56.9-66.2) | 46.1 (40.9-51.3) | 39.6 (33.6-45.5) | 356 | 94.2 (90.7-96.4) | 90.4 (85.5-93.7) | 86.3 (78.3-91.5) |
| Nervous system, NOS | 5,402 | 80.5 (79.4-81.6) | 73.0 (71.6-74.4) | 68.8 (67.1-70.5) | 2,648 | 64.1 (62.2-66.0) | 51.2 (49.0-53.4) | 45.5 (43.0-48.1) | 2,687 | 97.7 (96.9-98.3) | 95.0 (93.6-96.1) | 92.5 (90.4-94.1) |
| Meninges | 400,534 | 93.2 (93.1-93.3) | 88.0 (87.8-88.2) | 83.2 (82.9-83.4) | 6,053 | 83.7 (82.7-84.7) | 67.4 (65.9-68.8) | 60.4 (58.5-62.1) | 394,835 | 93.4 (93.3-93.5) | 88.4 (88.2-88.5) | 83.6 (83.3-83.8) |
| Cerebral meninges | 326,051 | 93.2 (93.1-93.3) | 87.9 (87.7-88.0) | 82.9 (82.6-83.2) | 4,350 | 84.6 (83.4-85.8) | 67.3 (65.6-69.0) | 60.2 (58.1-62.3) | 321,967 | 93.3 (93.2-93.4) | 88.2 (88.0-88.4) | 83.2 (83.0-83.5) |
| Spinal meninges | 17,771 | 97.4 (97.0-97.7) | 96.2 (95.5-96.8) | 94.2 (92.9-95.2) | 446 | 86.2 (82.4-89.2) | 75.9 (70.7-80.2) | 72.2 (65.7-77.8) | 17,345 | 97.7 (97.4-98.0) | 96.8 (96.0-97.3) | 94.9 (93.6-95.9) |
| Meninges, NOS | 56,712 | 92.1 (91.8-92.4) | 86.1 (85.6-86.5) | 81.2 (80.5-81.9) | 1,257 | 79.6 (77.1-81.9) | 64.5 (61.1-67.6) | 56.3 (52.2-60.2) | 55,523 | 92.4 (92.1-92.7) | 86.6 (86.2-87.1) | 81.9 (81.2-82.6) |
| Pituitary and craniopharyngeal duct | 190,594 | 98.0 (97.9-98.0) | 96.4 (96.2-96.6) | 94.4 (94.1-94.6) | 1,341 | 87.5 (85.5-89.3) | 76.5 (73.7-79.0) | 68.6 (65.1-71.8) | 189,384 | 98.0 (97.9-98.1) | 96.5 (96.4-96.7) | 94.6 (94.3-94.8) |
| Pituitary gland | 185,121 | 98.1 (98.0-98.2) | 96.8 (96.6-96.9) | 94.9 (94.6-95.2) | 1,315 | 87.8 (85.8-89.6) | 76.9 (74.1-79.5) | 69.0 (65.5-72.2) | 183,937 | 98.2 (98.1-98.3) | 96.9 (96.7-97.1) | 95.1 (94.8-95.4) |
| Craniopharyngeal duct | 5,473 | 92.5 (91.7-93.2) | 84.8 (83.6-85.9) | 77.7 (76.0-79.2) | 26 | 72.9 (50.4-86.5) | -- | -- | 5,447 | 92.6 (91.8-93.3) | 85.0 (83.8-86.1) | 77.9 (76.2-79.4) |
| Pineal gland | 4,344 | 91.8 (90.9-92.6) | 82.4 (81.0-83.6) | 77.6 (75.9-79.2) | 2,956 | 90.0 (88.8-91.0) | 76.8 (75.1-78.4) | 71.4 (69.4-73.3) | 1,661 | 94.5 (93.2-95.6) | 91.0 (89.0-92.6) | 87.1 (84.3-89.5) |
aThe cohort analysis of survival rates was utilized for calculating the survival estimates presented in this table. Long term cohort-based survival estimates reflect the survival experience of individuals diagnosed over the time period, and they may not necessarily reflect the long-term survival outlook of newly diagnosed cases.
bRates are an estimate of the percentage of patients alive at one, two, five, and ten years, respectively.
cAssigned behavior code of /3 (see Table 2).
dAssigned behavior code of /0 or /1 (see Table 2).
eTotal number of cases that occurred within the included NPCR and SEER registries between 2001 and 2019.
fTotal number of cases that occurred within the included NPCR and SEER registries between 2004-2019.
g ICD-O-3 histopathology codes 9522-9523 only.
--Rates were not presented for categories with 50 or fewer cases and were suppressed for rates where fewer than 16 cases were surviving within a category.
** Confidence interval could not be calculated.
Abbreviations: CBTRUS, Central Brain Tumor of the United States; NPCR, National program of Cancer Registries; RS, relative survival; CI, confidence interval; NOS, not otherwise specified.