Table 5.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals of Brain and Other Central Nervous System Tumors by Sitec and Sex, CBTRUS Statistical Report: US Cancer Statistics – NPCR and SEER, 2016-2020
| Site (ICD-O-3 Topography Code) | Total | Male | Female | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | 5-Year Total | Annual Average | % of all tumors | Rate (95% CI) | |
| Olfactory tumors of the nasal cavity (C30.0) d | 712 | 142 | 0.2% | 0.04 (0.04-0.04) | 418 | 84 | 0.2% | 0.05 (0.04-0.05) | 294 | 59 | 0.1% | 0.03 (0.03-0.04) |
| Meninges (cerebral and spinal) (C70.0-C70.9) | 186,065 | 37,213 | 41.0% | 9.78 (9.73-9.82) | 50,964 | 10,193 | 27.3% | 5.85 (5.80-5.90) | 135,101 | 27,020 | 50.6% | 13.27 (13.20-13.35) |
| Cerebral meninges (C70.0) | 153,072 | 30,614 | 33.7% | 8.05 (8.01-8.09) | 42,258 | 8,452 | 22.6% | 4.85 (4.80-4.90) | 110,814 | 22,163 | 41.5% | 10.90 (10.83-10.96) |
| Spinal meninges (C70.1) | 7,687 | 1,537 | 1.7% | 0.40 (0.39-0.41) | 1,684 | 337 | 0.9% | 0.19 (0.18-0.20) | 6,003 | 1,201 | 2.2% | 0.58 (0.56-0.59) |
| Meninges, NOS (C70.9) | 25,306 | 5,061 | 5.6% | 1.33 (1.32-1.35) | 7,022 | 1,404 | 3.8% | 0.81 (0.79-0.83) | 18,284 | 3,657 | 6.9% | 1.80 (1.77-1.82) |
| Cerebrum (C71.0) | 7,395 | 1,479 | 1.6% | 0.42 (0.41-0.43) | 3,930 | 786 | 2.1% | 0.46 (0.45-0.48) | 3,465 | 693 | 1.3% | 0.38 (0.37-0.39) |
| Frontal, temporal, parietal, and occipital lobes of the brain (C71.1-C71.4) | 77,432 | 15,486 | 17.1% | 4.17 (4.14-4.20) | 43,561 | 8,712 | 23.3% | 4.95 (4.90-5.00) | 33,871 | 6,774 | 12.7% | 3.48 (3.44-3.51) |
| Frontal lobe (C71.1) | 34,377 | 6,875 | 7.6% | 1.88 (1.86-1.90) | 18,398 | 3,680 | 9.8% | 2.12 (2.09-2.15) | 15,979 | 3,196 | 6.0% | 1.66 (1.64-1.69) |
| Temporal lobe (C71.2) | 24,982 | 4,996 | 5.5% | 1.34 (1.32-1.35) | 14,974 | 2,995 | 8.0% | 1.69 (1.66-1.72) | 10,008 | 2,002 | 3.8% | 1.03 (1.01-1.05) |
| Parietal lobe (C71.3) | 14,371 | 2,874 | 3.2% | 0.76 (0.74-0.77) | 8,127 | 1,625 | 4.4% | 0.91 (0.89-0.93) | 6,244 | 1,249 | 2.3% | 0.62 (0.61-0.64) |
| Occipital lobe (C71.4) | 3,702 | 740 | 0.8% | 0.19 (0.19-0.20) | 2,062 | 412 | 1.1% | 0.23 (0.22-0.24) | 1,640 | 328 | 0.6% | 0.16 (0.16-0.17) |
| Ventricle (C71.5) | 4,109 | 822 | 0.9% | 0.25 (0.24-0.26) | 2,284 | 457 | 1.2% | 0.28 (0.27-0.29) | 1,825 | 365 | 0.7% | 0.22 (0.21-0.23) |
| Cerebellum (C71.6) | 9,189 | 1,838 | 2.0% | 0.57 (0.56-0.58) | 4,987 | 997 | 2.7% | 0.63 (0.61-0.64) | 4,202 | 840 | 1.6% | 0.51 (0.50-0.53) |
| Brain stem (C71.7) | 6,092 | 1,218 | 1.3% | 0.39 (0.38-0.40) | 3,273 | 655 | 1.8% | 0.41 (0.40-0.43) | 2,819 | 564 | 1.1% | 0.36 (0.35-0.37) |
| Other brain (C71.8-C71.9) | 33,622 | 6,724 | 7.4% | 1.81 (1.79-1.83) | 18,065 | 3,613 | 9.7% | 2.08 (2.05-2.12) | 15,557 | 3,111 | 5.8% | 1.58 (1.55-1.61) |
| Overlapping lesion of brain (C71.8) | 12,747 | 2,549 | 2.8% | 0.67 (0.66-0.69) | 7,251 | 1,450 | 3.9% | 0.82 (0.80-0.84) | 5,496 | 1,099 | 2.1% | 0.55 (0.54-0.57) |
| Brain, NOS (C71.9) | 20,875 | 4,175 | 4.6% | 1.14 (1.12-1.16) | 10,814 | 2,163 | 5.8% | 1.27 (1.24-1.29) | 10,061 | 2,012 | 3.8% | 1.03 (1.01-1.05) |
| Spinal cord and cauda equina (C72.0-C72.1) | 12,423 | 2,485 | 2.7% | 0.72 (0.71-0.74) | 6,613 | 1,323 | 3.5% | 0.79 (0.77-0.81) | 5,810 | 1,162 | 2.2% | 0.66 (0.64-0.68) |
| Spinal cord (C72.0) | 12,028 | 2,406 | 2.7% | 0.70 (0.69-0.71) | 6,407 | 1,281 | 3.4% | 0.77 (0.75-0.79) | 5,621 | 1,124 | 2.1% | 0.64 (0.62-0.66) |
| Cauda equina (C72.1) | 395 | 79 | 0.1% | 0.02 (0.02-0.02) | 206 | 41 | 0.1% | 0.02 (0.02-0.03) | 189 | 38 | 0.1% | 0.02 (0.02-0.02) |
| Cranial nerves (C72.2-C72.5) | 30,362 | 6,072 | 6.7% | 1.67 (1.65-1.69) | 14,325 | 2,865 | 7.7% | 1.63 (1.61-1.66) | 16,037 | 3,207 | 6.0% | 1.70 (1.68-1.73) |
| Olfactory nerve (C72.2) | 46 | 9 | 0.0% | 0.00 (0.00-0.00) | 21 | 4 | 0.0% | 0.00 (0.00-0.00) | 25 | 5 | 0.0% | 0.00 (0.00-0.00) |
| Optic nerve (C72.3) | 1,796 | 359 | 0.4% | 0.12 (0.12-0.13) | 833 | 167 | 0.4% | 0.11 (0.10-0.12) | 963 | 193 | 0.4% | 0.13 (0.12-0.14) |
| Acoustic nerve (C72.4) | 22,280 | 4,456 | 4.9% | 1.20 (1.18-1.21) | 10,563 | 2,113 | 5.7% | 1.18 (1.16-1.21) | 11,717 | 2,343 | 4.4% | 1.21 (1.19-1.23) |
| Cranial nerve, NOS (C72.5) | 6,240 | 1,248 | 1.4% | 0.35 (0.34-0.35) | 2,908 | 582 | 1.6% | 0.33 (0.32-0.35) | 3,332 | 666 | 1.2% | 0.36 (0.35-0.37) |
| Other nervous system (C72.8-C72.9) | 2,439 | 488 | 0.5% | 0.13 (0.13-0.14) | 1,205 | 241 | 0.6% | 0.14 (0.13-0.15) | 1,234 | 247 | 0.5% | 0.13 (0.12-0.14) |
| Overlapping lesion of brain & CNS (C72.8) | 378 | 76 | 0.1% | 0.02 (0.02-0.02) | 194 | 39 | 0.1% | 0.02 (0.02-0.03) | 184 | 37 | 0.1% | 0.02 (0.02-0.02) |
| Nervous system, NOS (C72.9) | 2,061 | 412 | 0.5% | 0.11 (0.11-0.12) | 1,011 | 202 | 0.5% | 0.12 (0.11-0.13) | 1,050 | 210 | 0.4% | 0.11 (0.10-0.12) |
| Pituitary (C75.1- C75.2) | 82,172 | 16,434 | 18.1% | 4.78 (4.74-4.81) | 36,209 | 7,242 | 19.4% | 4.21 (4.17-4.26) | 45,963 | 9,193 | 17.2% | 5.43 (5.38-5.49) |
| Pituitary gland (C75.1) | 80,083 | 16,017 | 17.7% | 4.65 (4.62-4.69) | 35,107 | 7,021 | 18.8% | 4.08 (4.03-4.12) | 44,976 | 8,995 | 16.9% | 5.32 (5.27-5.37) |
| Craniopharyngeal duct (C75.2) | 2,089 | 418 | 0.5% | 0.12 (0.12-0.13) | 1,102 | 220 | 0.6% | 0.13 (0.13-0.14) | 987 | 197 | 0.4% | 0.12 (0.11-0.12) |
| Pineal (C75.3) | 1,611 | 322 | 0.4% | 0.10 (0.10-0.11) | 967 | 193 | 0.5% | 0.12 (0.12-0.13) | 644 | 129 | 0.2% | 0.08 (0.07-0.09) |
| TOTAL | 453,623 | 90,725 | 100.0% | 24.83 (24.75-24.90) | 186,801 | 37,360 | 100.0% | 21.62 (21.52-21.72) | 266,822 | 53,364 | 100.0% | 27.85 (27.74-27.96) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cThe sites referred to in this table are loosely based on the categories and site codes defined in the SEER site/histopathology validation list.
d ICD-O-3 histopathology codes 9522-9523 only.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; US, United States; CI, confidence interval; NOS, Not otherwise specified.