Table 6.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals for All Brain and Other Central Nervous System Tumors by Major Histopathology Grouping, Histopathology, Behavior, and Sex, CBTRUS Statistical Report: US Cancer Statistics – NPCR and SEER, 2016-2020
| Histopathology | Total | Males | Females | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | % of all tumors | Median Age | Rate (95% CI) | 5-Year Total | Annual Average | % Malignantc | Rate (95% CI) | 5-Year Total | Annual Average | % Malignant | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 84,389 | 16,878 | 18.6 | 63 | 4.45 (4.42-4.48) | 48,666 | 9,733 | 100.0 | 5.44 (5.39-5.49) | 35,723 | 7,145 | 100.0 | 3.58 (3.54-3.61) |
| Diffuse astrocytoma | 7,436 | 1,487 | 1.6 | 45 | 0.44 (0.43-0.45) | 4,167 | 833 | 99.9 | 0.51 (0.49-0.52) | 3,269 | 654 | 99.9 | 0.38 (0.37-0.40) |
| Anaplastic astrocytoma | 6,729 | 1,346 | 1.5 | 52 | 0.39 (0.38-0.40) | 3,718 | 744 | 100.0 | 0.44 (0.43-0.46) | 3,011 | 602 | 100.0 | 0.34 (0.32-0.35) |
| Glioblastoma | 64,548 | 12,910 | 14.2 | 66 | 3.27 (3.24-3.29) | 37,609 | 7,522 | 100.0 | 4.09 (4.05-4.14) | 26,939 | 5,388 | 100.0 | 2.55 (2.52-2.58) |
| Oligodendroglioma | 3,599 | 720 | 0.8 | 44 | 0.23 (0.22-0.23) | 2,000 | 400 | 100.0 | 0.25 (0.24-0.27) | 1,599 | 320 | 100.0 | 0.20 (0.19-0.21) |
| Anaplastic oligodendroglioma | 1,838 | 368 | 0.4 | 49 | 0.11 (0.10-0.11) | 1,040 | 208 | 99.8 | 0.13 (0.12-0.13) | 798 | 160 | 100.0 | 0.09 (0.09-0.10) |
| Oligoastrocytic tumors | 239 | 48 | 0.1 | 47 | 0.01 (0.01-0.02) | 132 | 26 | 100.0 | 0.02 (0.01-0.02) | 107 | 21 | 100.0 | 0.01 (0.01-0.02) |
| Other Astrocytic Tumors | 6,351 | 1,270 | 1.4 | 12 | 0.43 (0.42-0.44) | 3,393 | 679 | 89.3 | 0.45 (0.44-0.47) | 2,958 | 592 | 89.3 | 0.41 (0.39-0.42) |
| Pilocytic astrocytoma | 5,417 | 1,083 | 1.2 | 11 | 0.37 (0.36-0.38) | 2,894 | 579 | 95.4 | 0.39 (0.37-0.40) | 2,523 | 505 | 94.4 | 0.35 (0.34-0.36) |
| Unique astrocytoma variants | 934 | 187 | 0.2 | 18 | 0.06 (0.06-0.07) | 499 | 100 | 54.1 | 0.07 (0.06-0.07) | 435 | 87 | 59.5 | 0.06 (0.05-0.06) |
| Malignant | 529 | 106 | 0.1 | -- | 0.03 (0.03-0.04) | 270 | 54 | -- | 0.03 (0.03-0.04) | 259 | 52 | 100.0 | 0.03 (0.03-0.04) |
| Non-Malignant | 405 | 81 | 0.1 | -- | 0.03 (0.03-0.03) | 229 | 46 | -- | 0.03 (0.03-0.04) | 176 | 35 | 0.0 | 0.02 (0.02-0.03) |
| Ependymal Tumors | 6,858 | 1,372 | 1.5 | 46 | 0.41 (0.40-0.42) | 3,953 | 791 | 52.2 | 0.48 (0.46-0.50) | 2,905 | 581 | 60.2 | 0.35 (0.33-0.36) |
| Malignant | 3,813 | 763 | 0.8 | -- | 0.23 (0.23-0.24) | 2,063 | 413 | -- | 0.25 (0.24-0.27) | 1,750 | 350 | -- | 0.21 (0.20-0.22) |
| Non-Malignant | 3,045 | 609 | 0.7 | -- | 0.18 (0.17-0.19) | 1,890 | 378 | -- | 0.23 (0.22-0.24) | 1,155 | 231 | -- | 0.13 (0.13-0.14) |
| Other Gliomas | 8,977 | 1,795 | 2.0 | 38 | 0.55 (0.54-0.56) | 4,574 | 915 | 99.6 | 0.58 (0.56-0.59) | 4,403 | 881 | 99.4 | 0.53 (0.52-0.55) |
| Glioma malignant, NOS | 8,877 | 1,775 | 2.0 | 38 | 0.54 (0.53-0.56) | 4,535 | 907 | 100.0 | 0.57 (0.55-0.59) | 4,342 | 868 | 100.0 | 0.52 (0.51-0.54) |
| Other neuroepithelial tumors | 100 | 20 | 0.0 | 37.5 | 0.01 (0.01-0.01) | 39 | 8 | 48.7 | 0.01 (0.00-0.01) | 61 | 12 | 59.0 | 0.01 (0.01-0.01) |
| Malignant | 55 | 11 | 0.0 | -- | 0.00 (0.00-0.00) | 19 | 4 | -- | 0.00 (0.00-0.00) | 36 | 7 | -- | 0.00 (0.00-0.01) |
| Non-Malignant | 45 | 9 | 0.0 | -- | 0.00 (0.00-0.00) | 20 | 4 | -- | 0.00 (0.00-0.00) | 25 | 5 | -- | 0.00 (0.00-0.00) |
| Neuronal and Mixed Neuronal-Glial Tumors | 5,304 | 1,061 | 1.2 | 26 | 0.34 (0.33-0.35) | 2,860 | 572 | 18.2 | 0.37 (0.35-0.38) | 2,444 | 489 | 16.7 | 0.31 (0.30-0.33) |
| Malignant | 928 | 186 | 0.2 | -- | 0.05 (0.05-0.06) | 520 | 104 | -- | 0.06 (0.06-0.07) | 408 | 82 | -- | 0.05 (0.04-0.05) |
| Non-Malignant | 4,376 | 875 | 1.0 | -- | 0.29 (0.28-0.29) | 2,340 | 468 | -- | 0.30 (0.29-0.32) | 2,036 | 407 | -- | 0.27 (0.25-0.28) |
| Choroid Plexus Tumors | 808 | 162 | 0.2 | 20.5 | 0.05 (0.05-0.06) | 393 | 79 | 17.8 | 0.05 (0.05-0.06) | 415 | 83 | 12.8 | 0.05 (0.05-0.06) |
| Malignant | 123 | 25 | 0.0 | -- | 0.01 (0.01-0.01) | 70 | 14 | -- | 0.01 (0.01-0.01) | 53 | 11 | -- | 0.01 (0.01-0.01) |
| Non-Malignant | 685 | 137 | 0.2 | -- | 0.04 (0.04-0.05) | 323 | 65 | -- | 0.04 (0.04-0.05) | 362 | 72 | -- | 0.05 (0.04-0.05) |
| Tumors of The Pineal Region | 740 | 148 | 0.2 | 35 | 0.05 (0.04-0.05) | 336 | 67 | 68.5 | 0.04 (0.04-0.05) | 404 | 81 | 55.7 | 0.05 (0.05-0.06) |
| Malignant | 455 | 91 | 0.1 | -- | 0.03 (0.03-0.03) | 230 | 46 | -- | 0.03 (0.03-0.03) | 225 | 45 | -- | 0.03 (0.02-0.03) |
| Non-Malignant | 285 | 57 | 0.1 | -- | 0.02 (0.02-0.02) | 106 | 21 | -- | 0.01 (0.01-0.02) | 179 | 36 | -- | 0.02 (0.02-0.03) |
| Embryonal Tumors | 3,057 | 611 | 0.7 | 8 | 0.21 (0.20-0.22) | 1,826 | 365 | 100.0 | 0.25 (0.24-0.26) | 1,231 | 246 | 100.0 | 0.17 (0.16-0.18) |
| Tumors of Cranial and Spinal Nerves | 36,614 | 7,323 | 8.1 | 58 | 2.00 (1.98-2.03) | 17,670 | 3,534 | 0.6 | 2.01 (1.98-2.04) | 18,944 | 3,789 | 0.5 | 2.00 (1.97-2.03) |
| Nerve sheath tumors | 36,586 | 7,317 | 8.1 | 58 | 2.00 (1.98-2.02) | -- | -- | -- | -- | -- | -- | -- | -- |
| Malignant | 213 | 43 | 0.0 | -- | 0.01 (0.01-0.01) | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 36,373 | 7,275 | 8.0 | -- | 1.99 (1.97-2.01) | -- | -- | -- | -- | -- | -- | -- | -- |
| Other tumors of cranial and spinal nerves | 28 | 6 | 0.0 | 55.5 | 0.00 (0.00-0.00) | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 191,055 | 38,211 | 42.1 | 67 | 10.06 (10.02-10.11) | 53,423 | 10,685 | 2.2 | 6.14 (6.08-6.19) | 137,632 | 27,526 | 0.9 | 13.56 (13.49-13.64) |
| Meningiomas | 185,195 | 37,039 | 40.8 | 67 | 9.73 (9.68-9.77) | 50,439 | 10,088 | 1.4 | 5.79 (5.73-5.84) | 134,756 | 26,951 | 0.6 | 13.24 (13.16-13.31) |
| Malignant | 1,571 | 314 | 0.3 | -- | 0.08 (0.08-0.09) | 728 | 146 | -- | 0.08 (0.08-0.09) | 843 | 169 | -- | 0.08 (0.08-0.09) |
| Non-Malignant | 183,624 | 36,725 | 40.5 | -- | 9.64 (9.60-9.69) | 49,711 | 9,942 | -- | 5.70 (5.65-5.76) | 133,913 | 26,783 | -- | 13.15 (13.08-13.23) |
| Mesenchymal tumors | 5,718 | 1,144 | 1.3 | 51 | 0.33 (0.32-0.34) | 2,897 | 579 | 14.1 | 0.34 (0.33-0.36) | 2,821 | 564 | 13.3 | 0.32 (0.31-0.33) |
| Malignant | 783 | 157 | 0.2 | -- | 0.05 (0.04-0.05) | 408 | 82 | -- | 0.05 (0.04-0.05) | 375 | 75 | -- | 0.04 (0.04-0.05) |
| Non-Malignant | 4,935 | 987 | 1.1 | -- | 0.29 (0.28-0.29) | 2,489 | 498 | -- | 0.29 (0.28-0.31) | 2,446 | 489 | -- | 0.28 (0.27-0.29) |
| Primary melanocytic lesions | 142 | 28 | 0.0 | 60 | 0.01 (0.01-0.01) | 87 | 17 | 70.1 | 0.01 (0.01-0.01) | 55 | 11 | 58.2 | 0.01 (0.00-0.01) |
| Malignant | 93 | 19 | 0.0 | -- | 0.01 (0.00-0.01) | 61 | 12 | -- | 0.01 (0.01-0.01) | 32 | 6 | -- | 0.00 (0.00-0.01) |
| Non-Malignant | 49 | 10 | 0.0 | -- | 0.00 (0.00-0.00) | 26 | 5 | -- | 0.00 (0.00-0.00) | 23 | 5 | -- | 0.00 (0.00-0.00) |
| Lymphomas and Hematopoietic Neoplasms | 8,628 | 1,726 | 1.9 | 67 | 0.44 (0.44-0.45) | 4,360 | 872 | 99.8 | 0.49 (0.47-0.50) | 4,268 | 854 | 99.7 | 0.41 (0.40-0.42) |
| Lymphoma | 8,583 | 1,717 | 1.9 | 67 | 0.44 (0.43-0.45) | 4,336 | 867 | 99.8 | 0.48 (0.47-0.50) | 4,247 | 849 | 99.7 | 0.41 (0.39-0.42) |
| Other hematopoietic neoplasms | 45 | 9 | 0.0 | 64 | 0.00 (0.00-0.00) | 24 | 5 | 91.7 | 0.00 (0.00-0.00) | 21 | 4 | 95.2 | 0.00 (0.00-0.00) |
| Germ Cell Tumors | 1,255 | 251 | 0.3 | 15 | 0.08 (0.08-0.09) | 908 | 182 | 89.9 | 0.12 (0.11-0.13) | 347 | 69 | 79.5 | 0.05 (0.04-0.05) |
| Malignant | 1,092 | 218 | 0.2 | -- | 0.07 (0.07-0.08) | 816 | 163 | -- | 0.11 (0.10-0.11) | 276 | 55 | -- | 0.04 (0.03-0.04) |
| Non-Malignant | 163 | 33 | 0.0 | -- | 0.01 (0.01-0.01) | 92 | 18 | -- | 0.01 (0.01-0.02) | 71 | 14 | -- | 0.01 (0.01-0.01) |
| Tumors of Sellar Region | 81,166 | 16,233 | 17.9 | 51 | 4.72 (4.69-4.75) | 35,834 | 7,167 | 0.2 | 4.17 (4.12-4.21) | 45,332 | 9,066 | 0.1 | 5.36 (5.31-5.41) |
| Tumors of the pituitary | 78,082 | 15,616 | 17.2 | 51 | 4.54 (4.50-4.57) | 34,249 | 6,850 | 0.2 | 3.97 (3.93-4.02) | 43,833 | 8,767 | 0.1 | 5.19 (5.14-5.24) |
| Malignant | 98 | 20 | 0.0 | -- | 0.01 (0.00-0.01) | 65 | 13 | -- | 0.01 (0.01-0.01) | 33 | 7 | -- | 0.00 (0.00-0.01) |
| Non-Malignant | 77,984 | 15,597 | 17.2 | -- | 4.53 (4.50-4.56) | 34,184 | 6,837 | -- | 3.97 (3.92-4.01) | 43,800 | 8,760 | -- | 5.18 (5.13-5.23) |
| Craniopharyngioma | 3,084 | 617 | 0.7 | 46 | 0.18 (0.18-0.19) | 1,585 | 317 | 0.4 | 0.19 (0.18-0.20) | 1,499 | 300 | 0.1 | 0.18 (0.17-0.19) |
| Unclassified Tumors | 18,421 | 3,684 | 4.1 | 65 | 1.02 (1.01-1.04) | 8,605 | 1,721 | 39.1 | 1.04 (1.02-1.06) | 9,816 | 1,963 | 36.1 | 1.01 (0.99-1.03) |
| Hemangioma | 4,380 | 876 | 1.0 | 51 | 0.26 (0.25-0.26) | 2,025 | 405 | 0.0 | 0.24 (0.23-0.26) | 2,355 | 471 | 0.0 | 0.27 (0.26-0.28) |
| Neoplasm, unspecified | 13,506 | 2,701 | 3.0 | 70 | 0.73 (0.72-0.74) | 6,288 | 1,258 | 53.1 | 0.76 (0.74-0.78) | 7,218 | 1,444 | 48.5 | 0.71 (0.70-0.73) |
| Malignant | 6,836 | 1,367 | 1.5 | -- | 0.36 (0.35-0.37) | 3,336 | 667 | -- | 0.40 (0.39-0.41) | 3,500 | 700 | -- | 0.32 (0.31-0.34) |
| Non-Malignant | 6,670 | 1,334 | 1.5 | -- | 0.37 (0.36-0.38) | 2,952 | 590 | -- | 0.36 (0.34-0.37) | 3,718 | 744 | -- | 0.39 (0.37-0.40) |
| All other | 535 | 107 | 0.1 | 36 | 0.03 (0.03-0.04) | 292 | 58 | 10.6 | 0.04 (0.03-0.04) | 243 | 49 | 16.5 | 0.03 (0.03-0.03) |
| Malignant | 71 | 14 | 0.0 | -- | 0.00 (0.00-0.01) | 31 | 6 | -- | 0.00 (0.00-0.01) | 40 | 8 | -- | 0.01 (0.00-0.01) |
| Non-Malignant | 464 | 93 | 0.1 | -- | 0.03 (0.03-0.03) | 261 | 52 | -- | 0.03 (0.03-0.04) | 203 | 41 | -- | 0.02 (0.02-0.03) |
| TOTAL d | 453,623 | 90,725 | 100.0 | 62 | 24.83 (24.75-24.90) | 186,801 | 37,360 | 37.9 | 21.62 (21.52-21.72) | 266,822 | 53,364 | 20.9 | 27.85 (27.74-27.96) |
| Malignant | 126,729 | 25,346 | 27.9 | -- | 6.94 (6.91-6.98) | 70,865 | 14,173 | -- | 8.17 (8.11-8.23) | 55,864 | 11,173 | -- | 5.86 (5.81-5.91) |
| Non-Malignant | 326,894 | 65,379 | 72.1 | -- | 17.88 (17.82-17.95) | 115,936 | 23,187 | -- | 13.44 (13.37-13.52) | 210,958 | 42,192 | -- | 21.99 (21.89-22.09) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cAssigned behavior code of /3 (see table 2).
d Refers to all brain tumors including histopathologies not presented in this table.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified.