Table 8.
Five-Year Total, Annual Average Totala, and Average Annual Age-Adjusted Incidence Ratesb with 95% Confidence Intervals of Brain and Other Central Nervous System Tumors by Histopathology and NCI Age Group, CBTRUS Statistical Report: US Cancer Statistics – NPCR and SEER, 2016-2020
| Histopathology | Childrenc (0-14 years) | AYAd (15-39 years) | Older Adults (40+ years) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | |
| Diffuse Astrocytic and Oligodendroglial Tumors | 1,256 | 251 | 0.42 (0.39-0.44) | 9,733 | 1,947 | 1.81 (1.78-1.85) | 73,400 | 14,680 | 8.64 (8.57-8.70) |
| Diffuse astrocytoma | 563 | 113 | 0.19 (0.17-0.20) | 2,637 | 527 | 0.48 (0.47-0.50) | 4,236 | 847 | 0.54 (0.52-0.56) |
| Anaplastic astrocytoma | 193 | 39 | 0.06 (0.06-0.07) | 2,023 | 405 | 0.37 (0.35-0.39) | 4,513 | 903 | 0.56 (0.54-0.58) |
| Glioblastoma | 426 | 85 | 0.14 (0.13-0.16) | 3,089 | 618 | 0.58 (0.56-0.61) | 61,033 | 12,207 | 7.04 (6.99-7.10) |
| Oligodendroglioma | 54 | 11 | 0.02 (0.01-0.02) | 1,398 | 280 | 0.26 (0.25-0.28) | 2,147 | 429 | 0.30 (0.29-0.31) |
| Anaplastic oligodendroglioma | -- | -- | -- | -- | -- | -- | 1,318 | 264 | 0.17 (0.16-0.18) |
| Oligoastrocytic tumors | -- | -- | -- | -- | -- | -- | 153 | 31 | 0.02 (0.02-0.02) |
| Other Astrocytic Tumors | 3,712 | 742 | 1.23 (1.19-1.27) | 1,874 | 375 | 0.34 (0.33-0.36) | 765 | 153 | 0.10 (0.10-0.11) |
| Pilocytic astrocytoma | 3,333 | 667 | 1.10 (1.06-1.14) | 1,497 | 299 | 0.28 (0.26-0.29) | 587 | 117 | 0.08 (0.07-0.09) |
| Unique astrocytoma variants | 379 | 76 | 0.13 (0.11-0.14) | 377 | 75 | 0.07 (0.06-0.08) | 178 | 36 | 0.02 (0.02-0.03) |
| Malignant | 133 | 27 | 0.04 (0.04-0.05) | 261 | 52 | 0.05 (0.04-0.05) | 135 | 27 | 0.02 (0.01-0.02) |
| Non-Malignant | 246 | 49 | 0.08 (0.07-0.09) | 116 | 23 | 0.02 (0.02-0.03) | 43 | 9 | 0.01 (0.00-0.01) |
| Ependymal Tumors | 893 | 179 | 0.30 (0.28-0.32) | 1,869 | 374 | 0.35 (0.33-0.36) | 4,096 | 819 | 0.52 (0.51-0.54) |
| Malignant | 781 | 156 | 0.26 (0.24-0.28) | 976 | 195 | 0.18 (0.17-0.19) | 2,056 | 411 | 0.26 (0.25-0.27) |
| Non-Malignant | 112 | 22 | 0.04 (0.03-0.04) | 893 | 179 | 0.17 (0.16-0.18) | 2,040 | 408 | 0.26 (0.25-0.27) |
| Other Gliomas | 2,692 | 538 | 0.89 (0.86-0.93) | 1,936 | 387 | 0.36 (0.34-0.37) | 4,349 | 870 | 0.54 (0.52-0.56) |
| Glioma malignant, NOS | 2,670 | 534 | 0.88 (0.85-0.92) | 1,904 | 381 | 0.35 (0.34-0.37) | 4,303 | 861 | 0.53 (0.52-0.55) |
| Other neuroepithelial tumors | 22 | 4 | 0.01 (0.00-0.01) | 32 | 6 | 0.01 (0.00-0.01) | 46 | 9 | 0.01 (0.00-0.01) |
| Neuronal and Mixed Neuronal-Glial Tumors | 1,395 | 279 | 0.46 (0.44-0.49) | 2,166 | 433 | 0.40 (0.38-0.42) | 1,743 | 349 | 0.23 (0.22-0.24) |
| Malignant | 84 | 17 | 0.03 (0.02-0.03) | 177 | 35 | 0.03 (0.03-0.04) | 667 | 133 | 0.08 (0.08-0.09) |
| Non-Malignant | 1,311 | 262 | 0.43 (0.41-0.46) | 1,989 | 398 | 0.36 (0.35-0.38) | 1,076 | 215 | 0.15 (0.14-0.16) |
| Choroid Plexus Tumors | 351 | 70 | 0.12 (0.10-0.13) | 208 | 42 | 0.04 (0.03-0.04) | 249 | 50 | 0.03 (0.03-0.04) |
| Malignant | 93 | 19 | 0.03 (0.02-0.04) | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 258 | 52 | 0.09 (0.08-0.10) | -- | -- | -- | -- | -- | -- |
| Tumors of The Pineal Region | 145 | 29 | 0.05 (0.04-0.06) | 269 | 54 | 0.05 (0.04-0.06) | 326 | 65 | 0.04 (0.04-0.05) |
| Malignant | 128 | 26 | 0.04 (0.04-0.05) | 164 | 33 | 0.03 (0.03-0.03) | 163 | 33 | 0.02 (0.02-0.02) |
| Non-Malignant | 17 | 3 | 0.01 (0.00-0.01) | 105 | 21 | 0.02 (0.02-0.02) | 163 | 33 | 0.02 (0.02-0.03) |
| Embryonal Tumors | 2,076 | 415 | 0.69 (0.66-0.72) | 726 | 145 | 0.13 (0.12-0.14) | 255 | 51 | 0.04 (0.03-0.04) |
| Medulloblastoma | 1,429 | 286 | 0.47 (0.45-0.50) | 622 | 124 | 0.11 (0.10-0.12) | 159 | 32 | 0.02 (0.02-0.03) |
| Atypical teratoid/rhabdoid tumor | 349 | 70 | 0.12 (0.10-0.13) | -- | -- | -- | -- | -- | -- |
| All other embryonal | 298 | 60 | 0.10 (0.09-0.11) | -- | -- | -- | -- | -- | -- |
| Tumors of Cranial and Spinal Nerves | 565 | 113 | 0.19 (0.17-0.20) | 5,445 | 1,089 | 1.03 (1.00-1.06) | 30,604 | 6,121 | 3.72 (3.67-3.76) |
| Nerve sheath tumors | 565 | 113 | 0.19 (0.17-0.20) | -- | -- | -- | 30,579 | 6,116 | 3.71 (3.67-3.76) |
| Malignant | -- | -- | -- | -- | -- | -- | 147 | 29 | 0.02 (0.02-0.02) |
| Non-Malignant | -- | -- | -- | -- | -- | -- | 30,432 | 6,086 | 3.69 (3.65-3.74) |
| Other tumors of cranial and spinal nerves | -- | -- | -- | -- | -- | -- | 25 | 5 | 0.00 (0.00-0.00) |
| Tumors of Meninges | 663 | 133 | 0.22 (0.20-0.24) | 11,845 | 2,369 | 2.29 (2.25-2.33) | 178,547 | 35,709 | 21.39 (21.29-21.49) |
| Meningiomas | -- | -- | -- | -- | -- | -- | 174,626 | 34,925 | 20.90 (20.80-21.00) |
| Malignant | -- | -- | -- | -- | -- | -- | 1,468 | 294 | 0.17 (0.17-0.18) |
| Non-Malignant | -- | -- | -- | -- | -- | -- | 173,158 | 34,632 | 20.73 (20.63-20.83) |
| Mesenchymal tumors | 349 | 70 | 0.12 (0.10-0.13) | 1,557 | 311 | 0.29 (0.27-0.30) | 3,812 | 762 | 0.48 (0.46-0.49) |
| Malignant | 66 | 13 | 0.02 (0.02-0.03) | 169 | 34 | 0.03 (0.03-0.04) | 548 | 110 | 0.07 (0.06-0.07) |
| Non-Malignant | 283 | 57 | 0.09 (0.08-0.11) | 1,388 | 278 | 0.26 (0.24-0.27) | 3,264 | 653 | 0.41 (0.39-0.42) |
| Primary melanocytic lesions | -- | -- | -- | -- | -- | -- | 109 | 22 | 0.01 (0.01-0.02) |
| Lymphomas and Hematopoietic Neoplasms | 83 | 17 | 0.03 (0.02-0.03) | 526 | 105 | 0.10 (0.09-0.11) | 8,019 | 1,604 | 0.94 (0.92-0.96) |
| Lymphoma | -- | -- | -- | -- | -- | -- | 7,978 | 1,596 | 0.93 (0.91-0.95) |
| Other hematopoietic neoplasms | -- | -- | -- | -- | -- | -- | 41 | 8 | 0.00 (0.00-0.01) |
| Germ Cell Tumors | 556 | 111 | 0.18 (0.17-0.20) | 627 | 125 | 0.11 (0.11-0.12) | 72 | 14 | 0.01 (0.01-0.01) |
| Malignant | 478 | 96 | 0.16 (0.14-0.17) | 585 | 117 | 0.11 (0.10-0.12) | 29 | 6 | 0.00 (0.00-0.01) |
| Non-Malignant | 78 | 16 | 0.03 (0.02-0.03) | 42 | 8 | 0.01 (0.01-0.01) | 43 | 9 | 0.01 (0.00-0.01) |
| Tumors of Sellar Region | 1,772 | 354 | 0.58 (0.56-0.61) | 24,202 | 4,840 | 4.47 (4.41-4.52) | 55,192 | 11,038 | 6.99 (6.93-7.05) |
| Tumors of the pituitary | 1,155 | 231 | 0.38 (0.36-0.40) | 23,522 | 4,704 | 4.34 (4.29-4.40) | 53,405 | 10,681 | 6.77 (6.71-6.83) |
| Malignant | -- | -- | -- | -- | -- | -- | 80 | 16 | 0.01 (0.01-0.01) |
| Non-Malignant | -- | -- | -- | -- | -- | -- | 53,325 | 10,665 | 6.76 (6.70-6.82) |
| Craniopharyngioma | 617 | 123 | 0.20 (0.19-0.22) | 680 | 136 | 0.13 (0.12-0.14) | 1,787 | 357 | 0.22 (0.21-0.23) |
| Unclassified Tumors | 977 | 195 | 0.32 (0.30-0.34) | 2,812 | 562 | 0.52 (0.50-0.54) | 14,632 | 2,926 | 1.78 (1.75-1.81) |
| Hemangioma | 279 | 56 | 0.09 (0.08-0.10) | 1,196 | 239 | 0.22 (0.21-0.23) | 2,905 | 581 | 0.37 (0.35-0.38) |
| Neoplasm, unspecified | 547 | 109 | 0.18 (0.17-0.20) | 1,484 | 297 | 0.28 (0.26-0.29) | 11,475 | 2,295 | 1.38 (1.35-1.41) |
| Malignant | 173 | 35 | 0.06 (0.05-0.07) | 374 | 75 | 0.07 (0.06-0.08) | 6,289 | 1,258 | 0.75 (0.73-0.77) |
| Non-Malignant | 374 | 75 | 0.12 (0.11-0.14) | 1,110 | 222 | 0.21 (0.19-0.22) | 5,186 | 1,037 | 0.63 (0.62-0.65) |
| All other | 151 | 30 | 0.05 (0.04-0.06) | 132 | 26 | 0.02 (0.02-0.03) | 252 | 50 | 0.03 (0.03-0.04) |
| Malignant | 37 | 7 | 0.01 (0.01-0.02) | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 114 | 23 | 0.04 (0.03-0.05) | -- | -- | -- | -- | -- | -- |
| TOTAL e | 17,136 | 3,427 | 5.67 (5.58-5.75) | 64,238 | 12,848 | 12.00 (11.90-12.09) | 372,249 | 74,450 | 44.97 (44.82-45.12) |
| Malignant | 11,209 | 2,242 | 3.71 (3.64-3.78) | 17,285 | 3,457 | 3.21 (3.16-3.26) | 98,235 | 19,647 | 11.64 (11.57-11.72) |
| Non-Malignant | 5,927 | 1,185 | 1.96 (1.91-2.01) | 46,953 | 9,391 | 8.79 (8.71-8.87) | 274,014 | 54,802 | 33.33 (33.20-33.46) |
aAnnual average cases are calculated by dividing the five-year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cChildren as defined by the National Cancer Institute, see: http://www.cancer.gov/researchandfunding/snapshots/pediatric.
dAdolescents and Young Adults (AYA), as defined by the National Cancer Institute, see: http://www.cancer.gov/cancertopics/aya.
e Refers to all brain tumors including histopathologies not presented in this table.
-- Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: AYA, Adolescents and Young Adults; CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results Program; CI, confidence interval; NOS, not otherwise specified