Table 1.

Stage-specific proportions and 95% CIs of hepatocellular carcinomas overall and by sex and race/ethnicity in the USA, SEER-12 registries with specialised staging over time fields, 1992–2019.

All		Stage 1			Stage 2			Stage 3			Stage 4			Stage unknown
		Cases	%	95% CI	Cases	%	95% CI	Cases	%	95% CI	Cases	%	95% CI	Cases	%	95% CI
Non-Hispanic White	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	381 506 756 1,033 1,500 2,052 2,067	22 23 30 31 33 38 39	(20% 24%) (21% 25%) (28% 31%) (29% 32%) (31% 34%) (36% 39%) (38% 41%)	228 385 499 733 1,015 1,157 950	13 18 20 22 22 21 18	(12% 15%) (16% 19%) (18% 21%) (20% 23%) (21% 23%) (20% 22%) (17% 19%)	248 328 430 545 835 973 917	14 15 17 16 18 18 17	(13% 16%) (14% 17%) (15% 18%) (15% 17%) (17% 19%) (17% 19%) (16% 18%)	336 420 465 609 803 825 843	20 19 18 18 18 15 16	(18% 21%) (18% 21%) (17% 20%) (17% 19%) (16% 19%) (14% 16%) (15% 17%)	520 537 396 459 427 461 495	30 25 16 14 9 8 9	(28% 33%) (23% 26%) (14% 17%) (12% 15%) (8% 10%) (8% 9%) (9% 10%)
Non-Hispanic Black	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	57 80 124 247 345 488 439	19 18 21 28 31 35 32	(14% 23%) (15% 22%) (18% 25%) (25% 31%) (28% 33%) (33% 38%) (30% 35%)	40 93 119 177 225 263 224	13 21 21 20 20 19 16	(9% 17%) (17% 25%) (17% 24%) (17% 23%) (18% 22%) (17% 21%) (14% 18%)	55 79 119 181 232 272 295	18 18 21 20 21 20 22	(14% 22%) (14% 22%) (17% 24%) (18% 23%) (18% 23%) (17% 22%) (19% 24%)	72 99 125 208 218 251 273	24 23 22 23 19 18 20	(19% 28%) (19% 26%) (18% 25%) (21% 26%) (17% 22%) (16% 20%) (18% 22%)	81 89 92 73 105 116 136	27 20 16 8 9 8 10	(22% 32%) (16% 24%) (13% 19%) (6% 10%) (8% 11%) (7% 10%) (8% 12%)
Hispanic	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	120 206 333 519 728 1,051 1,038	22 24 28 31 32 37 36	(19% 26%) (22% 27%) (26% 31%) (28% 33%) (30% 34%) (35% 39%) (34% 37%)	91 152 256 360 517 573 568	17 18 22 21 23 20 19	(14% 20%) (15% 21%) (19% 24%) (19% 23%) (21% 24%) (19% 22%) (18% 21%)	71 122 185 308 373 465 473	13 14 16 18 16 16 16	(10% 16%) (12% 17%) (14% 18%) (16% 20%) (15% 18%) (15% 18%) (15% 18%)	113 157 194 297 368 406 412	21 19 17 17 16 14 14	(17% 24%) (16% 21%) (14% 19%) (16% 19%) (15% 18%) (13% 16%) (13% 15%)	145 205 207 217 287 349 427	27 24 18 13 13 12 15	(23% 31%) (21% 27%) (15% 20%) (11% 14%) (11% 14%) (11% 13%) (13% 16%)
Asian/Pacific Islander	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	229 342 504 720 870 1,057 993	20 23 27 32 34 40 39	(18% 23%) (21% 25%) (25% 29%) (30% 34%) (32% 36%) (38% 41%) (38% 41%)	192 302 395 483 509 459 397	17 20 22 21 20 17 16	(15% 19%) (18% 22%) (20% 23%) (20% 23%) (18% 22%) (16% 19%) (14% 17%)	225 324 404 480 511 526 525	20 22 22 21 20 20 21	(18% 22%) (19% 24%) (20% 24%) (20% 23%) (19% 22%) (18% 21%) (19% 22%)	188 272 292 350 356 383 348	17 18 16 16 14 14 14	(14% 19%) (16% 20%) (14% 18%) (14% 17%) (13% 15%) (13% 16%) (12% 15%)	295 266 242 221 297 250 251	26 18 13 10 12 9 10	(24% 29%) (16% 20%) (12% 15%) (9% 11%) (10% 13%) (8% 10%) (9% 11%)
American Indian/Alaska Native	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	15 15 30 35 63 94 90	32 34 40 28 34 43 35	(19% 45%) (20% 48%) (29% 51%) (20% 36%) (27% 41%) (36% 49%) (29% 41%)	6 10 9 33 30 40 56	13 23 12 26 16 18 22	(3% 22%) (10% 35%) (5% 19%) (19% 34%) (11% 22%) (13% 23%) (17% 27%)	9 6 16 18 30 39 31	19 14 21 14 16 18 12	(8% 30%) (3% 24%) (12% 31%) (8% 21%) (11% 22%) (13% 23%) (8% 16%)	11 ≤5 12 20 35 29 33	23 9 16 16 19 13 13	(11% 36%) (1% 18%) (8% 24%) (10% 22%) (13% 25%) (9% 18%) (9% 17%)	6 9 8 19 26 19 47	13 20 11 15 14 9 18	(3% 22%) (9% 32%) (4% 18%) (9% 21%) (9% 19%) (5% 12%) (14% 23%)
Men
Non-Hispanic White	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	278 362 547 786 1,157 1,575 1,558	22 23 29 30 32 36 38	(20% 25%) (21% 25%) (27% 31%) (28% 32%) (30% 33%) (35% 38%) (36% 39%)	169 285 388 572 797 933 753	14 18 20 22 22 21 18	(12% 15%) (16% 20%) (19% 22%) (20% 23%) (21% 23%) (20% 23%) (17% 19%)	173 236 327 432 666 806 728	14 15 17 16 18 19 18	(12% 16%) (13,% .17%) (15% 19%) (15% 18%) (17% 20%) (17% 20%) (17% 19%)	254 328 355 486 653 662 690	20 21 19 18 18 15 17	(18% 23%) (19% 23%) (17% 20%) (17% 20%) (17% 19%) (14% 16%) (16% 18%)	376 386 286 356 347 365 388	30 24 15 14 10 8 9	(28% 33%) (22% 26%) (13% 17%) (12% 15%) (9% 11%) (8% 9%) (9% 10%)
Non-Hispanic Black	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	39 50 85 184 255 358 312	17 16 19 27 29 33 31	(13% 22%) (12% 20%) (15% 23%) (24% 30%) (26% 32%) (31% 36%) (28% 33%)	33 66 93 136 187 198 167	15 21 21 20 21 19 16	(13% 17%) (19% 23%) (19% 22%) (18% 21%) (20% 23%) (17% 20%) (15% 18%)	46 64 91 137 187 217 216	21 20 20 20 21 20 21	(18% 23%) (18% 22%) (18% 22%) (18% 21%) (20% 23%) (19% 21%) (20% 22%)	48 70 105 170 182 206 211	22 22 23 25 21 19 21	(19% 24%) (20% 24%) (21% 25%) (23% 26%) (19% 22%) (18% 20%) (19% 22%)	57 66 76 59 70 91 114	26 21 17 9 8 9 11	(23% 28%) (19% 23%) (15% 19%) (8% 10%) (7% 9%) (8% 9%) (10% 12%)
Hispanic	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	75 134 233 360 536 733 702	17 16 19 27 29 33 31	(15% 23%) (19% 25%) (24% 30%) (26% 30%) (29% 33%) (33% 37%) (31% 35%)	68 120 187 288 388 423 416	17 20 22 22 23 20 19	(14% 20%) (17% 22%) (19% 24%) (20% 24%) (21% 24%) (18% 22%) (18% 21%)	56 84 148 236 299 363 367	14 14 17 18 17 17 17	(12% 16%) (12% 16%) (15% 19%) (16% 20%) (16% 19%) (16% 19%) (15% 19%)	89 123 140 242 291 319 323	22 20 16 19 17 15 15	(19% 25%) (18% 23%) (14% 18%) (17% 21%) (15% 19%) (14% 17%) (13% 17%)	110 148 158 158 209 265 330	28 24 18 12 12 13 15	(25% 31%) (22% 27%) (16% 20%) (11% 14%) (11% 14%) (11% 14%) (14% 17%)
Asian/Pacific Islander	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	163 251 319 495 587 714 689	20 23 24 30 32 37 38	(17% 23%) (21% 26%) (22% 27%) (28% 33%) (30% 34%) (35% 39%) (35% 40%)	139 213 287 351 359 343 298	17 20 22 22 20 18 16	(3% 31%) (4% 35%) (11% 33%) (13% 30%) (13% 27%) (12% 24%) (11% 22%)	164 240 305 373 385 398 395	20 22 23 23 21 21 22	(5% 35%) (6% 38%) (12% 35%) (14% 32%) (14% 28%) (14% 27%) (16% 28%)	134 203 229 269 285 313 267	16 19 18 17 16 16 15	(2% 30%) (3% 34%) (7% 28%) (9% 24%) (9% 22%) (10% 22%) (9% 20%)	214 183 168 142 201 158 183	26 17 13 9 11 8 10	(10% 43%) (2% 31%) (4% 22%) (3% 15%) (6% 16%) (4% 13%) (6% 14%)
American Indian/Alaska Native	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	8 8 23 24 50 56 55	30 32 43 28 38 37 31	(12% 47%) (14% 50%) (30% 57%) (18% 37%) (30% 47%) (30% 45%) (24% 37%)	≤5 6 ≤5 23 19 29 44	19 24 9 26 15 19 25	(13% 24%) (19% 29%) (7% 12%) (23% 30%) (12% 17%) (17% 22%) (22% 27%)	≤5 ≤5 13 12 18 31 23	15 12 25 14 14 21 13	(10% 19%) (8% 16%) (21% 29%) (11% 16%) (12% 16%) (18% 23%) (11% 15%)	8 ≤5 7 16 29 24 25	30 8 13 18 22 16 14	(24% 36%) (5% 11%) (10% 16%) (15% 21%) (20% 25%) (14% 18%) (12% 16%)	≤5 6 ≤5 12 14 10 32	7 24 9 14 11 7 18	(4% 11%) (19% 29%) (7% 12%) (11% 16%) (9% 13%) (5% 8%) (16% 20%)
Women
Non-Hispanic White	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	103 144 209 247 343 477 509	22 25 33 33 36 42 44	(18% 26%) (21% 28%) (29% 36%) (30% 36%) (33% 39%) (39% 45%) (41% 47%)	59 100 111 161 218 224 197	13 17 17 22 23 20 17	(10% 16%) (14% 20%) (14% 20%) (19% 25%) (20% 25%) (18% 22%) (15% 19%)	75 92 103 113 169 167 189	16 16 16 15 18 15 16	(13% 20%) (13% 19%) (13% 19%) (13% 18%) (15% 20%) (13% 17%) (14% 18%)	82 92 110 123 150 163 153	18 16 17 16 16 14 13	(14% 21%) (13% 19%) (14% 20%) (14% 19%) (13% 18%) (12% 17%) (11% 15%)	144 151 110 103 80 96 107	31 26 17 14 8 9 9	(27% 35%) (23% 30%) (14% 20%) (11% 16%) (7% 10%) (7% 10%) (8% 11%)
Non-Hispanic Black	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	18 30 39 63 90 130 127	22 24 30 32 37 41 37	(13% 31%) (17% 32%) (22% 38%) (25% 38%) (31% 43%) (35% 46%) (32% 42%)	7 27 26 41 38 65 57	9 22 20 21 16 20 16	(2% 15%) (15% 29%) (13% 27%) (15% 26%) (11% 20%) (16% 25%) (13% 20%)	9 15 28 44 45 55 79	11 12 22 22 18 17 23	(4% 18%) (6% 18%) (15% 29%) (16% 28%) (14% 23%) (13% 21%) (18% 27%)	24 29 20 38 36 45 62	29 23 16 19 15 14 18	(19% 39%) (16% 31%) (9% 22%) (14% 24%) (10% 19%) (10% 18%) (14% 22%)	24 23 16 14 35 25 22	29 19 12 7 14 8 6	(19% 39%) (12% 25%) (7% 18%) (3% 11%) (10% 19%) (5% 11%) (4% 9%)
Hispanic	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	45 72 100 159 192 318 336	32 31 32 38 35 43 43	(24% 39%) (25% 37%) (27% 38%) (33% 43%) (31% 39%) (39% 46%) (40% 47%)	23 32 69 72 129 150 152	16 14 22 17 23 20 19	(10% 22%) (9% 18%) (18% 27%) (14% 21%) (20% 27%) (17% 23%) (17% 22%)	15 38 37 72 74 102 106	11 16 12 17 13 14 14	(6% 16%) (12% 21%) (8% 16%) (14% 21%) (11% 16%) (11% 16%) (11% 16%)	24 34 54 55 77 87 89	17 15 17 13 14 12 11	(11% 23%) (10% 19%) (13% 22%) (10% 16%) (11% 17%) (9% 14%) (9% 14%)	35 57 49 59 78 84 97	25 24 16 14 14 11 12	(18% 32%) (19% 30%) (12% 20%) (11% 17%) (11% 17%) (9% 14%) (10% 15%)
Asian/Pacific Islander	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	66 91 185 225 283 343 304	21 22 35 36 39 46 45	(16% 25%) (18% 26%) (31% 39%) (32% 40%) (35% 43%) (42% 49%) (41% 48%)	53 89 108 132 150 116 99	17 21 20 21 21 15 15	(13% 21%) (17% 25%) (17% 24%) (18% 24%) (18% 24%) (13% 18%) (12% 17%)	61 84 99 107 126 128 130	19 20 19 17 17 17 19	(15% 24%) (16% 24%) (15% 22%) (14% 20%) (15% 20%) (14% 20%) (16% 22%)	54 69 63 81 71 70 81	17 17 12 13 10 9 12	(13% 21%) (13% 20%) (9% 15%) (10% 16%) (8% 12%) (7% 11%) (9% 14%)	≤5 ≤5 ≤5 7 12 9 15	26 20 14 13 13 12 10	(21% 31%) (16% 24%) (11% 17%) (10% 15%) (11% 16%) (10% 15%) (8% 12%)
American Indian/Alaska Native	1992–1995 1996–1999 2000–2003 2004–2007 2008–2011 2012–2015 2016–2019	7 7 7 11 13 38 35	35 37 32 29 24 54 45	(14% 56%) (15% 59%) (12% 51%) (15% 43%) (13% 35%) (42% 65%) (34% 56%)	≤5 ≤5 ≤5 10 11 11 12	5 21 18 26 20 15 15	(0% 15%) (3% 39%) (2% 34%) (12% 40%) (10% 31%) (7% 24%) (7% 23%)	≤5 ≤5 ≤5 6 12 8 8	25 16 14 16 22 11 10	(6% 44%) (0% 32%) (0% 28%) (4% 27%) (11% 33%) (4% 19%) (4% 17%)	≤5 ≤5 ≤5 ≤5 6 ≤5 8	15 11 23 11 11 7 10	(0% 31%) (0% 24%) (5% 40%) (1% 20%) (3% 19%) (1% 13%) (4% 17%)	≤5 ≤5 ≤5 7 12 9 15	20 16 14 18 22 13 19	(2% 38%) (0% 32%) (0% 28%) (6% 31%) (11% 33%) (5% 20%) (10% 28%)

SEER, Surveillance, Epidemiology and End Results.