Table 2.
Type of SCD and baseline biological parameters in sickle cell children with and without cholelithiasis and their relationship to cholelithiasis at the National Reference Center for Sickle Cell Disease.
| Characteristics | Cholelithiasis | Without cholelithiasis | OR | IC 95% | P | ||
|---|---|---|---|---|---|---|---|
| n | (%) | n | (%) | ||||
| Type of SCD | |||||||
| S/β thalassemia∗ | 6 | 16.22 | 21 | 28.38 | 0.57 | 0.25–1.29 | 0.16 |
| SS | 31 | 83.78 | 53 | 71.62 | 1.17 | 0.96–1.43 | |
| SC | 0 | — | 0 | — | |||
| Hb (g/dL) | |||||||
| <6 | 13 | 35.14 | 14 | 18.92 | 1.82 | 0.69–4.74 | 0.21 |
| ≥6 | 24 | 64.86 | 60 | 81.08 | 0.8 | 0.54–1.15 | |
| MCV∗∗ (FL) | |||||||
| <100 | 24 | 64.86 | 44 | 59.46 | 0.86 | 0.80–1.47 | 0.58 |
| ≥100 | 13 | 35.14 | 30 | 40.54 | 1.09 | 0.44–1.62 | |
| MCHC∗∗∗ (g/dL) | |||||||
| <32 | 19 | 51.35 | 23 | 31.08 | 1.26 | 0.63–2.52 | 0.81 |
| ≥32 | 18 | 48.65 | 51 | 68.92 | 0.85 | 0.53–1.38 | |
| WBC∗∗∗∗ (/mm3) | |||||||
| <12000 | 21 | 56.76 | 44 | 59.46 | 0.67 | 0.39–1.13 | 0.11 |
| ≥12000 | 16 | 43.24 | 30 | 40.54 | 1.7 | 0.85–3.38 | |
| Platelets (giga/L) | |||||||
| 150–450 | 31 | 83.78 | 56 | 75.68 | 1.28 | 0.89–1.82 | 0.17 |
| ≥450 | 6 | 16.22 | 18 | 24.32 | 0.51 | 0.18–1.41 | |
∗ Sickle beta-zero-thalassemia (5 cases vs 8 controls) and sickle beta-plus-thalassemia (1 case vs 13 controls). ∗∗Mean corpuscular volume. ∗∗∗Mean corpuscular Hb concentration. ∗∗∗∗White blood cells.