TABLE 1.

Baseline demographic and disease characteristics—all patients

Characteristic	Aspergillus	Candida	Othera	Total
Patients dosed (%)	33 (25)	67 (50)	33 (25)	133
Male/female ratio	20/13	40/27	26/7	86/47
Age (yr) [median (range)]	45 (6–77)	46 (1–84)	46 (16–86)	46 (1–86)
Underlying disease or condition
Hematologic malignancy	15	12	12	39 (29.3%)
Solid tumor	1	10	0	11 (8.3%)
Bone marrow transplant	9	24	12	45 (33.8%)
Solid organ transplant	4	4	1	9 (6.8%)
Otherb	4	17	8	29 (21.8%)
Site of infection
Lung	26	9	14	49 (36.8%)
Skin	2	0	2	4 (3.0%)
Blood and/or disseminated	0	30	2	32 (24.1%)
Sinus	1	0	2	3 (2.3%)
Otherc	4	28	14	46 (34.6%)
Enrollment reason
Amphotericin B toxicity	20	27	21	68 (51.1%)
Renal insufficiency	8	30	8	46 (34.6%)
Otherd	5	10	4	19 (14.3%)
Baseline laboratory measurement
ANCe (1,000/mm3) [mean (range)]	6.49 (0–31.1)	9.00 (0–38.8)	9.75 (0–160)	8.56 (0–160)
Serum creatinine (mg/dl) [mean (range)]	2.28 (0.6–4.9)	2.58 (0.8–7.2)	2.63 (1.1–6.7)	2.52 (0.6–7.2)
Total bilirubin (mg/dl) [mean (range)]	2.84 (0.4–22.0)	4.45 (0.2–43.0)	4.56 (0.3–33.8)	4.09 (0.3–33.8)

^aHistoplasma/Coccidioides, Cryptococcus, other molds, and other yeasts. 

^bOther underlying diseases or conditions included human immunodeficiency virus infection, AIDS, chronic obstructive pulmonary disease, surgery, coagulopathy, diabetes mellitus, chronic granulomatous disease, sarcoid tumor, Crohn’s disease, anemia, hypertension, immunosuppression, prosthesis, thrombocytopenia, or none. 

^cOther sites of infection included bone, brain, chest wall, central nervous system, esophagus, gastrointestinal culture, Hickman catheter, hip joint fluid, liver, oropharynx, peritoneum, spleen, and urinary tract; also, one patient had >1 site of infection. 

^dPatients did not meet entry criteria but were considered to be at risk of nephrotoxicity. 

^eANC, absolute neutrophil count.