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. Author manuscript; available in PMC: 2023 Oct 5.
Published in final edited form as: ACS Catal. 2021 Aug 18;11(17):10974–10987. doi: 10.1021/acscatal.1c03088

Figure 1.

Figure 1.

Representation of HS2ST and HS6ST. (A) General proposed catalytic mechanism exerted by HS2ST and HS6ST. (B) Surface representation of the HS2ST trimer. Each monomer is represented with a unique color. The insert highlights the glycan clamps (K111/R190 in cyan and R288/K350′ in purple) and the H142 catalytic base. (C) Surface representation of the HS6ST monomer. The insert highlights W153 and W210 near the active site, catalytic H153, and the loop containing the K131/K132 pair. The numbers indicate the position of the saccharide units in relation to the acceptor unit.