FIG. 3.

Case 3. Timeline of symptoms, imaging findings, and steroid dose according to treatment modality (upper). Axial T1-weighted sequences with contrast and axial FLAIR sequences at key time points (lower). Baseline MRI at the time of SRS (left) to a 1.5-cm melanoma metastasis shows significant edema. At 15 months (center), 5-Loxin was initiated after patient failed trimodal therapy to control ARE (imaging changes including irregular rim enhancement, central necrosis, increased edema compared to post-SRS scans). At 26 months (right), MRI shows resolution of AREs (minimal linear enhancement, no perilesional edema).