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. 2023 Oct 3;137(19):1533–1545. doi: 10.1042/CS20230499

Figure 1. Colchicine limited AAA formation in mice.

Figure 1

Male C57BL/6 mice were treated with porcine pancreatic elastase (PPE, 4U) incubation and 0.4% β-aminopropionitrile (BAPN) in drinking water for 2 weeks to induce abdominal aortic aneurysm (AAA). Colchicine (0.1 mg/kg/d, i.p.) was injected after operation for 2 weeks. (A) Representative images of mice aortas, scale bar = 4 mm, n = 4 per group. (B) Total aortic weight per body weight, n = 6 per group; incidence of AAA, n = 10 per group. (C) Representative images of HE, Masson, VVG staining, scale bar = 500 μm (up) or 100 μm (down). Colchicine treatment reduced maximal abdominal aortic diameter (D) and collagen deposition (E), and with no effects on elastin score evaluation (F) in AAA groups, n = 4 per group. Data were shown as mean ± SEM, **P<0.01 vs. Sham; #P<0.05, ##P<0.01 vs. AAA + Saline; ns, no significance.