Skip to main content
. 2023 Oct 3;137(19):1533–1545. doi: 10.1042/CS20230499

Figure 2. Colchicine prevented phenotypic switching of VSMCs in AAA mice.

Figure 2

Male C57BL/6 mice were treated with porcine pancreatic elastase (PPE, 4U) incubation and 0.4% β-aminopropionitrile (BAPN) in drinking water for 2 weeks to induce abdominal aortic aneurysm (AAA). Colchicine (0.1 mg/kg/d, i.p.) was injected after operation for 2 weeks. (A) Colchicine treatment up-regulated the expression of α-SMA and down-regulated OPN, PCNA, MMP9 and MMP2 in AAA tissues. (B) Representative images of immunofluorescence staining of α-SMA (red), OPN (red), PCNA (red), MMP9 (red) and MMP2 (red) in AAA tissues; nuclei were counterstained with DAPI (blue), scale bar = 100 μm. n = 3 per group, data were shown as mean ± SEM, *P<0.05, **P<0.01 vs. Sham; #P<0.05, ##P<0.01 vs. AAA + Saline; ns, no significance.