Table 2. Deubiquitinases that regulate replication fork stability.

Deubiquitinase	Substrate	Function	REF.
USP36	PRIMPOL	Enhances PRIMPOL stability at stressed forks	[40]
USP1	PCNA	Removes the monoubiquitin moiety from PCNA to switch off the TLS pathway	[41]
USP1/UAF1	FANCD2	Removes the monoubiquitin moiety from FANCD2 to enable efficient completion of DNA crosslink repair	[42–45]
USP10	PCNA	Cooperates with ISGylated PCNA to suppress the TLS pathway	[46]
USP7	SPRTN	Antagonizes the auto-cleavage and subsequent inactivation of SPRTN	[47]
USP11	SPRTN	Prevents auto-cleavage of monoubiquitinated SPRTN	[48]
VCPIP1/VCIP135	SPRTN	Promotes the relocalization of SPRTN onto chromatin	[49]

Abbreviations: TLS, translesion synthesis; TS, template-switching.