Table 1.
Sampling of tolerogenic proteins identified in JEG and JAR EVs via proteomics that correspond to primary trophoblast EV cargo [16, 48]
| Protein | Cell line | Function |
|---|---|---|
| Heat shock protein family E (Hsp10) member 1 (HSPE1) | JAR, JEG-3 | Regulate T cell expansion and Treg differentiation |
| CD276 | JAR, JEG-3 | Restrains T cell activation and proliferation |
| Programmed cell death protein 6 | JAR, JEG-3 | Apoptosis |
| Programmed cell death 6-interacting protein | JAR, JEG-3 | |
| CD81 antigen | JAR, JEG-3 | Regulation of complement cascade |
| Complement decay-accelerating factor (CD55) | JAR, JEG-3 | |
| Superoxide dismutase | JAR, JEG-3 | Anti-inflammatory enzyme |
| Galectin-1, 3 | JAR | Negative regulators of immune cell function |
| Galectin-7 | JAR, JEG-3 |