Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Oct 4;14:6203. doi: 10.1038/s41467-023-41805-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A–C (Left) Different types of dicentric chromosome breakage and their copy-number outcomes: (A) terminal; (B) paracentric; or (C) pericentric segmental copy number changes. The open and filled chromatids may be sister chromatids or different chromosomes. Both A and B were demonstrated in vitro in ref. ³⁸. The model that pericentric copy-number changes may arise from broken dicentric ring chromosomes (C) or multicentric chromosomes (when the p- and q-termini of a chromosome are fused to two other chromosomes) has not been demonstrated in vitro but is plausible as telomere crisis can lead to multiple shortened telomeres that generate dicentric rings. (Right) Examples of SCNAs in BE/EAC genomes that recapitulate the predicted SCNA outcomes of bridge resolution. The allelic copy-number plots (25 kb bins) show the DNA copy number of the altered chromosome; the intact homolog is not shown. Examples of gain and loss in each group are unrelated. See “Online Data” for the copy-number plots of both homologs in each sample. D Summary of terminal/internal SCNAs in BE/EAC genomes, including copy-number patterns consistent with different combinations of successive BFB cycles with SCNA outcomes shown in A–C. Numbers denote instances of each pattern. See Supplementary Data 5 for the complete list.