Table 3.
Additional loci associated with the multi-ancestry analysis
| Multi-ancestry discovery | European discovery | RIKEN - Biobank Japan | 23andMe Latino | 23andMe African | 23andMe European | Known | Novel | |||
|---|---|---|---|---|---|---|---|---|---|---|
| N = 992,907 | N = 864,982 | N = 118,287 | N = 525,348 | N = 174,015 | N = 2,904,664 | Associations | Associations | |||
| Variant | Chr:position | Alleles (EAF) | P | P | P | P | P | P | ||
| rs114059822a | 1:19804918 | T/G (0.03) | 8.59E−09 | 0.25 | – | 0.07 | 0.03 | 0.87 | NA | NA |
| rs9247 | 2:234113301 | T/C (0.21) | 1.92E−09 | 7.32E−08 | 7.71E−05 | 1.49E−13 | 7.23E−03 | 2.93E−51 | allb | |
| rs9864845 | 3:112383847 | A/G (0.37) | 2.17E−12 | 0.22 | 3.92E−13 | 0.75 | 0.23 | 0.12 | Japanese (Tanaka et al.8) | |
| rs34599047 | 6:106629690 | C/T (0.18) | 3.32E−08 | 1.29E−07 | 0.03 | 7.18E−04 | 0.02 | 3.23E−22 | allb | |
| rs7773987 | 6:135707486 | T/C (0.60) | 1.22E−08 | 9.57E−08 | 0.15 | 0.18 | 1.95E−03 | 5.93E−13 | European, African | |
| rs118029610a | 9:1894613 | T/C (0.03) | 1.89E−08 | 2.97E−04 | – | 0.5 | 0.31 | 0.78 | NA | NA |
| rs117137535 | 9:140500443 | A/G (0.03) | 1.99E−08 | 5.50E−08 | – | 3.99E−07 | 0.33 | 9.25E−19 | European (Grosche et al.7) | Latino |
| rs4312054 | 11:7977161 | G/T (0.43) | 3.21E−12 | 0.86 | 3.46E−15 | 0.4 | 0.33 | 0.52 | Japanese (Tanaka et al.8) | |
| rs150113720a | 11:83439186 | G/C (0.02) | 5.52E−10 | 0.40 | – | 0.1 | 0.22 | 0.14 | NA | NA |
| rs115148078a | 11:101361300 | T/C (0.02) | 5.91E−09 | 0.37 | – | 3.69E−03 | 0.91 | 0.89 | NA | NA |
| rs4262739 | 11:128421175 | A/G (0.50) | 2.20E−08 | 6.03E−07 | 2.28E−03 | 1.89E−06 | 0.09 | 1.45E−36 | European & Japanese (Tanaka et al.8) | Latino |
| rs1059513 | 12:57489709 | C/T (0.08) | 5.15E−09 | 1.57E−07 | 0.33 | 3.06E−04 | 0.17 | 6.95E−16 | European (Tanaka et al.8) | Latino |
| rs4574025 | 18:60009814 | T/C (0.55) | 7.00E−10 | 1.48E−06 | 2.67E−05 | 2.59E−04 | 1.24E-05 | 2.96E−05 | European & Japanese (Tanaka et al.8) | Latino, African |
| rs6023002 | 20:52797237 | C/G (0.52) | 4.05E−10 | 2.26E−06 | 2.82E−07 | 5.96E−03 | 0.07 | 3.22E−28 | European & Japanese (Tanaka et al.8) | Latino |
For loci that were associated in the multi-ancestry discovery analysis, but not the European discovery analysis, we show the (unadjusted two-sided) P-values for association across 4 diverse ancestral groups, European, Japanese, Latino and African. Full association statistics (including OR and 95% CI) for each variant can be viewed in Supplementary Data 4 (and results across all cohorts individually are depicted in Supplementary Fig. 2).
Alleles are reported as effect allele/other allele.
Genome build = GRCh37/hg19.
NA indicates finding not replicated and likely to be false-positive in discovery.
Bold is used in the novel column to denote the 3 associations that are entirely novel (i.e. locus has not been associated in any ancestry previously).
– Variant was not available in dataset.
aGenome-wide significant loci without replication that are assumed to be false positives in the discovery data.
bWhilst not identified in any GWAS AD papers, these loci have previously shown evidence for association with AD in the supplementary material of methodological papers92 or GWAS of combined allergic disease phenotype5.