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. 2023 Oct 4;14(10):648. doi: 10.1038/s41419-023-06154-8

Fig. 5. The relationship between ferroptosis and autophagy.

Fig. 5

Autophagy promotes ferroptosis by altering cellular iron content, lipid storage, redox homeostasis and energy status. During autophagy, the selective autophagy receptors NCOA4, RAB7A, and p62 bind and degrade substrates such as FTH1, lipid droplets, ARNTL, and SLC40A1. Moreover, autophagy can affect the expression of TFR1 and System XC-. The TCA cycle, ETC and the input of Fe2+ promote ferroptosis in mitochondria, and the input of GPX inhibits mitochondrial lipid peroxidation. DHODH1 and FSP1 are involved in inhibiting lipid peroxidation at the mitochondrial membrane and plasma membrane, respectively. This graph was drawn with Figdraw.