Table 1.

Drugs and other compounds that regulate ADCD.

Intervention Factors	Mechanism	Mode	Citation
RCD	–	Normal autophagy	[25, 27]
Bax/Bak KO	–		[26]
SH003	Activates ATF4 and inhibit G9a		[34]
Kaempferol	Activates IRE1-JNK-CHOP and inhibits G9a		[35]
Tunicamycin	Promotes ceramide synthesis through GBA1 action		[40]
Resveratrol	Activates GBA1 to promote ceramide synthesis		[65]
THC	Promotes dihydroceramide accumulation in lysosomes, which leads to LMP		[68]
ABTL0812	Promotes dihydroceramide accumulation, which activates the ATF4-DDIT3-TRIB3 pathway		[71]
Loperamide	Activates the ATF4-FAM134B axis and TEX264, leads to lipid accumulation in lysosomes and lipid ROS production	ER-phagy	[36, 47]
Z36	Activates FAM134B and the UPR		[37]
Sorafenib	Activates FAM134B		[38]
Activate smARF	smARF bind to parkin to promote mitophagy	Mitophagy	[58–60]
AT-101	Activate BNIP3, BNIP3L and HMOX1		[61]
THPN	TR3 translocation to mitochondrial gap change membrane potential		[62]
C18-Pyr-Cer	Activate CerS1/C18-Drp1		[64]
HPV	HPV E7-E2F5-Drp1-ceramide		[69]
Inhibition of FLT3-ITD	Activate Drp1-ceramide		[70]
Tat-Beclin	Activates Na+-K+ATPase	Autosis	[72]
Ischemia/Reperfusion	Activates Tfeb and inhibits Rubicon		[74, 75]
Tat-Beclin	Beclin1 binds to Na + -K + ATPase		[78]
Homocysteine and copper	Activates p22phox and NOX-mediated p62 upregulation		[80]