Table 2.

Drugs and other compounds that regulate cellular AMCD.

Intervention Factors	Mechanism	Mode	Citation
SKI and Bortezomib	Autophagosome provides a platform for Caspase-8 recruitment and activation	Apoptosis	[23]
Homocysteine and copper	Cleavage of ATG5 to block Bcl-2		[80]
Fas Ligand	Autophagosome phagocytosis of Fap-1 Inhibits Fas		[81]
ABT-737	Autophagosomes engulf mitochondria and inhibit IFN-β secretion		[82]
MG132	ATG12 binds to and inactivates Bcl-2		[83, 84]
Calpain	Calpain cleaves ATG5 to block Bcl-2		[85]
TRAIL and MAP3K7 KO,GX15-070	Autophagosome membrane platform promotes assembly of the necrosis complex	Necroptosis	[89]
Coxsackievirus B3	Activates RIPK3		[91]
TNF-α	RIPK3 activates AMPK to promote early autophagy and inhibit late autophagy		[92]
BAY 87-2243	Promotes ROS-dependent mitophagy		[93]
Erastin	Autophagosomes degrade FTH1, FTL, FTMT	Ferroptosis	[96–98]
	Autophagosomes degradation SLC40A1		[99]
	Autophagosomes degrade lipid droplets through RAB7A action		[100]
	Autophagosomes degrade ARNTL through the action of SQSTM1		[101]
	Partner-mediated autophagosome degradation of GPX4		[102]
	Autophagosomes degrades CDH2 through the action of HPCAL1		[103]
	ROS activates autophagy, upregulates TFR1 level		[116]
BAY 87-2243	Promotes ROS-dependent mitophagy		[93]
Inhibition of O-GlcNA acetylation	Induces mitophagy and iron-specific autophagy and promotes F2+ release		[97]
WJ460	Induces mitophagy		[111]
Celastrol and erastin	Induces autophagy and mitophagy		[115]