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. Author manuscript; available in PMC: 2024 Oct 5.
Published before final editing as: J Am Chem Soc. 2023 Apr 5:10.1021/jacs.2c11715. doi: 10.1021/jacs.2c11715

Figure 1.

Figure 1.

Rationale for a prodrug strategy to improve the cell-based selectivity of YM155 and proposed mechanism of action for RIPK2-dependent induced cell death. (A) Scheme providing a rationale for the YM155 prodrug strategy and design based on comparison of the chemical structures and properties of cRIPGBM to YM155 and of the corresponding RIPGBM and aYM155 prodrugs. (B) Schematic representation of the proposed mechanism of action for cRIPGBM and YM155-induced cell death.10 Predicted full length RIPK2 structure was generated using Alphafold.11