The differential abundances for the top 10 and bottom 10 with mean (bar) and model 95% confidence interval (error bars) associated with cognitive normal (more positive, blue) and mild cognitive impairment (more negative, red) (A, B, C). The log-ratio (y-axis) of the top and bottom bacterial strains (D&E) plotted across time (x-axis) and colored by cognitive status. Presented cognitive status p-values in log-ratio plots are determined from linear mixed effects models with fixed effects of diet, cognitive status, period, and diet sequences with random effect of subject.