Skip to main content
. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Alzheimers Dement. 2023 Apr 5;19(11):4805–4816. doi: 10.1002/alz.13007

Figure 4. Microbial strains (left), foods (middle), and metabolites (right) related to both cognitive status and diet.

Figure 4.

Scatter plot of log ratios of differential abundances by diet (x-axes) and cognitive status (y-axes) for microbes, with the ten most differential microbes and metabolites in both axes colored (A). Violin plot of the log-ratio of Alistepes sp. CAG: 514 to Bifidobacterium adolescentis at four different timepoints in the study (B). Scatter plot of log ratios of differential abundances by diet (x-axes) and cognitive status (y-axes) for microbes, with the ten most differential microbes and metabolites in both axes colored (C). Violin plot of the log-ratio of plant metabolites to Diarylheptanoids at four different timepoints in the study (D). In the scatterplots shown in (A) and (C), each corner corresponds to a different subpopulation: the top right corner represents microbes/metabolites associated with the MMKD and CN, the top left corner contains the microbes/metabolites correlated with the AHAD and CN, the bottom left corner shows microbes/metabolites associated with the AHAD and mild cognitive impairment, and the bottom right corner corresponds to microbes/metabolites correlated with the MMKD and MCI. These analyses allowed us to examine microbial and metabolite changes that were modulated by both diet and cognitive status.