Table 2.
Nonsynonymous variant with multiple mutation (> 1%) alleles shared among the cosmopolitan genotype DENV-2 isolates based on dengue severity
| Sample ID | WHO classification | Protein region | Nucleotide position | AA position | Reference allele | Alter allele | Frequency | Change |
|---|---|---|---|---|---|---|---|---|
| S-10, 13 | SD | NS1 | 2768 | 891 | A | G | 9% | K-R |
| S-5, 9 | SD | NS3 | 5207 | 1704 | C | T | 97% | A-V |
| S-8, 10 | SD | NS4B | 7097 | 2334 | T | C | 49% | V-A |
| S-12, 17, 30 | SD | NS4B | 7256 | 2387 | A | C | 8% | N-T |
| S-11, 16, 20 | SD | NS4B | 9676 | 3194 | T | C | 7% | W-R |
| S-20 | SD | NS4B | 9857 | 3254 | G | A | 86% | S-N |
| S-6, 11, 32 | SD | NS5 | 10286 | 3397 | C | T | 99% | S-L |
| S-23 | SD | NS5 | 10336 | 3414 | A | G | 98% | T-A |
| S-22, 27 | SD | NS5 | 10390 | 3432 | A | G | 98% | K-E |
| S-2, 8, 13, 18, 23, 29, 31, 33 | SD | NS5 | 10606 | 3504 | C | G | 7% | R-G |
| S-7, 28 | DWWS | NS2B | 4208 | 1371 | T | C | 94% | I-T |
| S-1 | DWWS | NS4B | 9676 | 3194 | T | C | 8% | W-R |
| S-1, 3 | DWWS | NS5 | 10286 | 3397 | C | T | 100% | S-L |
| S-3 | DWWS | NS5 | 10336 | 3414 | A | G | 99% | T-A |
| S-26 | DWWS | NS5 | 10390 | 3432 | A | G | 99% | K-E |
| S-3, 15, 25 | DWWS | NS5 | 10606 | 3504 | C | G | 21% | R-G |
| S-4, 19, 25 | DWoWS | NS5 | 10606 | 3504 | C | G | 19% | R-G |
| S-21 | DWoWS | NS4B | 9857 | 3254 | G | A | 95% | S-N |
| S-40 | DWoWS | NS5 | 10286 | 3397 | C | T | 99% | S-L |
| S-40 | DWoWS | NS5 | 10336 | 3414 | A | G | 99% | T-A |
AA position = amino acid position; DWoWS = dengue without warning signs; DWWS = dengue with warning signs; NS = nonstructural; SD = severe dengue. Reference strain (GenBank accession number: MT180479) was used.