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Oral administration of GS 4104 causes a reduction in the virus titers in the lungs of mice infected with influenza A/NWS/33 (H1N1) virus. Virus titers in lung homogenates of animals sacrificed at the indicated times after infection were determined as described in Materials and Methods for infected mice given oral dosages of 10 mg of GS 4104 per kg per day (○) or saline (•). Values are means ± standard deviations for at least six animals.
