FIG. 3.

Oral administration of GS 4104 reduces the febrile and inflammatory responses of ferrets infected with an influenza A (H3N2) virus. (A) The change in rectal temperature relative to the baseline temperatures obtained for the same animals prior to infection was determined at the indicated times after infection. (B) The total number of inflammatory cells was determined in nasal wash samples obtained from infected animals at the indicated times after infection. Ferrets were left untreated (×) or were treated twice daily with oral doses of GS 4104 of 5 mg/kg (○) or 25 mg/kg (•) for 3 days beginning 2 h after infection with influenza virus clone 7a. Values are means ± standard deviations for four animals.