TABLE 3.

Oral administration of GS 4104 protects mice against a lethal challenge with influenza virus

Virus	Dosage (mg/kg/day)a	No. of survivors/total no.	% Survivors
A/NWS/33 (H1N1)	10	8/8b	100
	1	7/8c	88
	0.1	2/8	25
	0d	2/16	13
A/Victoria/3/75 (H3N2)	10	8/8c	100
	1	5/8	63
	0.1	3/8	38
	0d	5/16	31
B/Hong Kong/5/72	10	8/10c	80
	3.2	9/10c	90
	1	1/10	10
	0d	2/18	11

^aGS 4104 was administered orally twice daily for 5 days beginning 4 h prior to infection with the indicated influenza virus. 

^bP < 0.001 compared to control animals in the same experiment. 

^cP < 0.01 compared to control animals in the same experiment. 

^dControl.