TABLE 4.

GS 4104 reduces peak nasal virus titers in ferrets infected with influenza A virus

Time (h) postinfection	Nasal wash virus titer (log10 TCID50s/ml)a
	Untreated	GS 4104 (25 mg/kg)	GS 4104 (5 mg/kg)
12	0.29 ± 0.81	0.21 ± 0.60	0.29 ± 0.83
24	0.31 ± 0.87	0.00 ± 0.00	0.00 ± 0.00
30b	4.70 ± 0.30	3.83 ± 0.29	4.46 ± 0.35
36	4.14 ± 0.34	2.91 ± 0.53	3.70 ± 0.45
48	3.59 ± 0.42	3.62 ± 0.38	3.18 ± 1.31
54	2.35 ± 1.49	3.20 ± 0.48	1.89 ± 1.68
60	3.03 ± 0.84	2.24 ± 0.53	2.78 ± 0.68
72	3.14 ± 0.86	2.33 ± 1.07	2.53 ± 0.97
78	2.49 ± 1.31	2.49 ± 1.32	2.50 ± 1.18

^aData represent the means ± standard deviations for duplicate measurements with the nasal wash samples obtained from four animals. 

^bPeak virus titers were detected at 30 h postinfection.