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. 2023 Sep 21;14:1225403. doi: 10.3389/fneur.2023.1225403

Table 2.

Association between serum folic acid and severe difficulty falling asleep, NHANES 2005–2008.

Model 1 Model 2 Model 3
OR (95%) OR (95%) OR (95%)
Serum folic acid (ng/ml) 0.99 (0.98, 1.00) 0.98 (0.97, 1.00) 0.99 (0.98, 1.00)
Serum folic acid (ng/ml, quartile)
 Q1 (0.70–9.50) Referrence Referrence Referrence
 Q2 (9.50–13.90) 0.69 (0.52, 0.91) 0.67 (0.51, 0.90) 0.77 (0.56, 1.05)
 Q3 (13.90–20.20) 0.65 (0.50, 0.85) 0.60 (0.46, 0.80) 0.72 (0.54, 0.97)
 Q4 (20.20–209.30) 0.62 (0.47, 0.81) 0.55 (0.40, 0.74) 0.70 (0.51, 0.96)
p for trend <0.001 <0.001 0.021

Model 1: no covariates were adjusted. Model 2: age, gender, and race/ethnicity were adjusted. Model 3: age, gender, race/ethnicity, education level, marital status, alcohol use, smoking status, BMI, hypertension, and diabetes were adjusted.