Table 3.

Subgroup analysis for regions and latitude distribution.

Studies	Number		Sensitivity	Specificity	PLR	NLHR	DOR	AUC
Regions	11	China	0.65(0.56-0.74)	0.74 (0.65-0.81)	2.5 (1.9-3.3)	0.47(0.37-0.60)	5(3–8)	0.75 (0.71-0.79)
	1	Korea	0.775	0.486	No result	No result	3(2–6)	0.64
	2	Taiwan	No result	No result	No result	No result	5(3–7)	No result
	1	Japan	0.81	0.77	No result	No result	12(3–57)	0.75
	1	Cote d’Ivoire	0.53	0.75	No result	No result	4(2–8)	0.68
Cutoff identification	12	ROC	0.68(0.63-0.73)	0.70(0.62-0.77)	2.3(1.8-2.8)	0.45(0.40-0.52)	5(4–7)	0.74(0.70-0.78)
Age	10	Median ag ≤55	0.63(0.53-0.73)	0.74(0.64-0.82)	2.5(1.8-3.4)	0.49(0.38-0.64)	5(3–8)	0.74(0.70-0.78)
	6	Median age >55	0.71(0.66-0.76)	0.68(0.57-0.77)	2.2(1.7-2.9)	0.42(0.36-0.50)	5(4–8)	0.75(0.71-0.79)
Gender	10	Male ≤200	0.64(0.56-0.72)	0.68(0.57-0.77)	2.0(1.6-2.5)	0.53(0.46-0.60)	4(3–5)	0.70(0.66-0.74)
	6	Male >200	0.69(0.58-0.78)	0.76(0.67-0.83)	2.9(2.0-4.2)	0.41(0.29-0.58)	7(4–13)	0.79(0.75-0.82)
Latitude distribution	8	High-latitude	0.72(0.63-0.79)	0.74 (0.65-0.81)	2.7 (2.0-3.8)	0.39(0.29-0.52)	7(4–12)	0.79 (0.75-0.82)
	8	Low-latitude	0.62 (0.51-0.72)	0.70 (0.58-0.80)	2.1 (1.6-2.6)	0.54 (0.47-0.63)	4(3–5)	0.71 (0.66-0.74)