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. 2023 Sep 21;14:1209249. doi: 10.3389/fimmu.2023.1209249

Figure 4.

Figure 4

TRAIL increases the expression of M1 markers in primary human M0 macrophages at the protein level. M0 macrophages were stimulated with 200 ng/ml TRAIL for 8 hours (CXCL10/CXCL1) or 18 hours (IDO/CD38/CXCL11). Control groups were left unstimulated. (A–D) The production of CXCL10, CXCL1, IDO, and CD38 was analyzed by flow cytometry, and the representative plots are included. (E) The production of CXCL11 was analyzed by ELISA. Data shown are mean ± SEM or median with interquartile range pooled from two or more independent experiments [(A) n=11, (B) n=10, (C) n=8, (D) n=9, (E) n= 5]. Statistical analyses were performed with a two-tailed paired Student’s t-test or Wilcoxon matched-pairs signed-rank test between untreated and TRAIL-treated macrophages, *P<0.05, **P<0.01.