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. 2023 Sep 21;14:1237727. doi: 10.3389/fendo.2023.1237727

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Copyright © 2023 Okoro, Orwoll, Huttenhower, Morgan, Kuntz, McIver, Dufour, Bouxsein, Langsetmo, Farsijani, Kado, Pacifici, Sahni and Kiel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between predicted metabolic pathways and bone measures. The metabolic pathways were predicted using PICRUSt2. Pathways - bone associations were calculated using MaAslin2 and all associations with an FDR<0.1 are shown. We adjusted for all covariates in the association models. For (A) the heatmap of associations in the FHS cohort are shown. The X and Y axes were clustered hierarchically. The "+" and "-" signs indicate the direction of association between microbial abundance on the vertical axis and bone measures along the horizontal axis. (B) is a table of the associations in MrOS.