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. 2023 Sep 21;14:1237727. doi: 10.3389/fendo.2023.1237727

Table 1B.

Measures of skeletal phenotypes obtained using High Resolution Peripheral Quantitative Computed Tomography HR-pQCT scans.

Skeletal Phenotypes Measured using HR-pQCT Scans
Phenotype FHS (N=1227) FHS Women (N=683) FHS Men (N=544) MrOS (N=836)
Mean (SD) Mean (SD) Mean (SD) Mean (SD)
Radius Bone Measures
r_Ct_Th 0.96 (0.21) 0.86 (0.17) 1.09 (0.19) 0.96 (0.22)
r_Ct_vBMD 873.3 (65.3) 876.3 (73.2) 869.6 (53.9) 799.1 (66.3)
r_CtBATA 0.19 (0.05) 0.19 (0.04) 0.20 (0.04) 0.17 (0.05)
r_Tb_Inn_vBMD 123.4 (40.4) 103.3 (33.0) 148.0 (34.7) 133.4 (41.1)
r_Tb_N 1.51 (0.24) 1.41 (0.22) 1.64 (0.20) 1.40 (0.21)
r_Tb_vBMD 161.6 (41.0) 141.0 (33.8) 186.8 (34.3) 170.2 (39.4)
r_Tot_vBMD 296.0 (61.2) 278.8 (57.6) 321.8 (55.3) 275.6 (60.2)
r_Total_Area 332.5 (75.9) 282.2 (42.5) 394.8 (61.3) 398.3 (64.9)
r_fail_load_FEA 2926.2 (1072.6) 2217.6 (573.5) 3815.2 (872.1) 4921.7 (1339.9)
Tibia Bone Measures
t_Ct_Th 1.62 (0.34) 1.44 (0.25) 1.83 (0.32) 1.49 (0.33)
t_Ct_vBMD 889.9 (76.0) 880.2 (88.1) 902.2 (54.8) 784.5 (78.1)
t_CtBATA 0.20 (0.04) 0.19 (0.04) 0.21 (0.04) 0.16 (0.04)
t_Tb_Inn_vBMD 121.2 (39.6) 108.0 (36.2) 137.8 (37.3) 135.3 (40.4)
t_Tb_N 1.39 (0.22) 1.35 (0.22) 1.44 (0.21) 1.34 (0.22)
t_Tb_vBMD 169.1 (41.5) 154.3 (37.6) 187.9 (38.4) 185.3 (38.5)
t_Tot_vBMD 309.2 (58.8) 287.6 (54.7) 336.3 (52.3) 281.9 (55.3)
t_Total_Area 744.0 (132.9) 670.1 (89.7) 836.9 (119.5) 893.5 (134.6)
t_fail_load_FEA 8468.6 (2355.6) 6880.5 (1321.3) 10466.1 (1780.0) 13691.8 (3009.8)

The FHS cohort participants is comprised of both men and women as broken down in the table, while the MrOS cohort participants is comprised of only men. All bone measures significantly differed between the two cohorts (p<0.05) except for radius cortical thickness. In the comparison of FHS Men and FHS Women, there was no statistical difference in HR-pQCT scan of radius cortical vBMD. The comparison of FHS Men and MrOS showed that there were no significant difference in the HR-pQCT scans of radius total area, and tibia trabecular vBMD and trabecular inner vBMD. The bone phenotypes were grouped based on bone site; radius (r) and tibia (t). Thus, bone variable names were prefixed with “r_” for radius bone measures, and “t_” for tibia bone measures. The bone phenotype labels are; Ct_Th, Cortical thickness (mm); Ct_vBMD, Average cortical vBMD (mg HA/cm3); CtBATA, Cortical bone area fraction, CtAr/TtAr; Tb_Inn_vBMD, Inner trabecular vBMD (mg HA/cm3); Tb_N, Trabecular number (1/mm); Tb_vBMD, Trabecular vBMD (mg HA/cm3); Tot_vBMD, Average total vBMD (mg HA/cm3); Total_Area, Total cross-sectional area (mm2); fail_load_FEA, Failure load, N.