Table 1B.
Skeletal Phenotypes Measured using HR-pQCT Scans | ||||
---|---|---|---|---|
Phenotype | FHS (N=1227) | FHS Women (N=683) | FHS Men (N=544) | MrOS (N=836) |
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
Radius Bone Measures | ||||
r_Ct_Th | 0.96 (0.21) | 0.86 (0.17) | 1.09 (0.19) | 0.96 (0.22) |
r_Ct_vBMD | 873.3 (65.3) | 876.3 (73.2) | 869.6 (53.9) | 799.1 (66.3) |
r_CtBATA | 0.19 (0.05) | 0.19 (0.04) | 0.20 (0.04) | 0.17 (0.05) |
r_Tb_Inn_vBMD | 123.4 (40.4) | 103.3 (33.0) | 148.0 (34.7) | 133.4 (41.1) |
r_Tb_N | 1.51 (0.24) | 1.41 (0.22) | 1.64 (0.20) | 1.40 (0.21) |
r_Tb_vBMD | 161.6 (41.0) | 141.0 (33.8) | 186.8 (34.3) | 170.2 (39.4) |
r_Tot_vBMD | 296.0 (61.2) | 278.8 (57.6) | 321.8 (55.3) | 275.6 (60.2) |
r_Total_Area | 332.5 (75.9) | 282.2 (42.5) | 394.8 (61.3) | 398.3 (64.9) |
r_fail_load_FEA | 2926.2 (1072.6) | 2217.6 (573.5) | 3815.2 (872.1) | 4921.7 (1339.9) |
Tibia Bone Measures | ||||
t_Ct_Th | 1.62 (0.34) | 1.44 (0.25) | 1.83 (0.32) | 1.49 (0.33) |
t_Ct_vBMD | 889.9 (76.0) | 880.2 (88.1) | 902.2 (54.8) | 784.5 (78.1) |
t_CtBATA | 0.20 (0.04) | 0.19 (0.04) | 0.21 (0.04) | 0.16 (0.04) |
t_Tb_Inn_vBMD | 121.2 (39.6) | 108.0 (36.2) | 137.8 (37.3) | 135.3 (40.4) |
t_Tb_N | 1.39 (0.22) | 1.35 (0.22) | 1.44 (0.21) | 1.34 (0.22) |
t_Tb_vBMD | 169.1 (41.5) | 154.3 (37.6) | 187.9 (38.4) | 185.3 (38.5) |
t_Tot_vBMD | 309.2 (58.8) | 287.6 (54.7) | 336.3 (52.3) | 281.9 (55.3) |
t_Total_Area | 744.0 (132.9) | 670.1 (89.7) | 836.9 (119.5) | 893.5 (134.6) |
t_fail_load_FEA | 8468.6 (2355.6) | 6880.5 (1321.3) | 10466.1 (1780.0) | 13691.8 (3009.8) |
The FHS cohort participants is comprised of both men and women as broken down in the table, while the MrOS cohort participants is comprised of only men. All bone measures significantly differed between the two cohorts (p<0.05) except for radius cortical thickness. In the comparison of FHS Men and FHS Women, there was no statistical difference in HR-pQCT scan of radius cortical vBMD. The comparison of FHS Men and MrOS showed that there were no significant difference in the HR-pQCT scans of radius total area, and tibia trabecular vBMD and trabecular inner vBMD. The bone phenotypes were grouped based on bone site; radius (r) and tibia (t). Thus, bone variable names were prefixed with “r_” for radius bone measures, and “t_” for tibia bone measures. The bone phenotype labels are; Ct_Th, Cortical thickness (mm); Ct_vBMD, Average cortical vBMD (mg HA/cm3); CtBATA, Cortical bone area fraction, CtAr/TtAr; Tb_Inn_vBMD, Inner trabecular vBMD (mg HA/cm3); Tb_N, Trabecular number (1/mm); Tb_vBMD, Trabecular vBMD (mg HA/cm3); Tot_vBMD, Average total vBMD (mg HA/cm3); Total_Area, Total cross-sectional area (mm2); fail_load_FEA, Failure load, N.