Table 2.
Associations between microbial genera abundance and bone measures in the FHS cohorts.
| ALL FHS Cohort Microbial Genera – Bone Associations, FDR=0.05 | |||||
|---|---|---|---|---|---|
| Genera | Phenotype | Beta | Stderr | P-val | Q-val |
| Cortical Bone Measures | |||||
| Akkermansia | r_Ct_Th | -0.586 | 0.169 | 5.69E-04 | 1.45E-02 |
| Blautia | t_Ct_Th | -0.266 | 0.060 | 1.17E-05 | 7.47E-04 |
| Candidatus_Stoquefichus | t_Ct_vBMD | -0.313 | 0.091 | 5.89E-04 | 1.20E-02 |
| Subdoligranulum | t_Ct_vBMD | 0.431 | 0.133 | 1.19E-03 | 2.01E-02 |
| Lachnospiraceae_ND3007_group | t_Ct_vBMD | 0.362 | 0.115 | 1.62E-03 | 2.43E-02 |
| Bacteroides | t_Ct_vBMD | -0.131 | 0.046 | 4.30E-03 | 4.71E-02 |
| Akkermansia | r_CtBATA | -0.472 | 0.145 | 1.13E-03 | 2.35E-02 |
| Defluviitaleaceae_UCG.011 | r_CtBATA | -0.239 | 0.08 | 2.74E-03 | 4.36E-02 |
| Blautia | t_CtBATA | -0.215 | 0.052 | 3.66E-05 | 1.46E-03 |
| Trabecular Bone Measures | |||||
| DTU089 | r_Tb_Inn_vBMD | -0.373 | 0.127 | 3.38E-03 | 4.92E-02 |
| DTU089 | t_Tb_Inn_vBMD | -0.386 | 0.109 | 3.91E-04 | 9.24E-03 |
| Victivallis | t_Tb_Inn_vBMD | 0.300 | 0.097 | 2.10E-03 | 3.00E-02 |
| DTU089 | t_Tb_vBMD | -0.341 | 0.111 | 2.14E-03 | 3.11E-02 |
| Victivallis | t_Tb_N | 0.294 | 0.096 | 2.12E-03 | 2.87E-02 |
| Lachnospiraceae_UCG.009 | r_Tb_N | 0.238 | 0.072 | 9.44E-04 | 2.30E-02 |
| Marvinbryantia | r_Tb_N | -0.448 | 0.139 | 1.29E-03 | 2.71E-02 |
| Total Bone Measures | |||||
| Akkermansia | r_Tot_vBMD | -0.456 | 0.147 | 1.96E-03 | 2.95E-02 |
| DTU089 | t_Tot_vBMD | -0.381 | 0.116 | 1.00E-03 | 1.87E-02 |
| Blautia | t_Tot_vBMD | -0.179 | 0.056 | 1.28E-03 | 2.16E-02 |
| Romboutsia | r_Total_Area | 0.620 | 0.184 | 7.82E-04 | 2.27E-02 |
| Defluviitaleaceae_UCG.011 | r_Total_Area | 0.381 | 0.115 | 9.88E-04 | 2.60E-02 |
| Ruminococcaceae_UCG.008 | r_Total_Area | 0.328 | 0.102 | 1.39E-03 | 3.15E-02 |
| Romboutsia | t_Total_Area | 0.536 | 0.143 | 1.79E-04 | 5.94E-03 |
| Dorea | t_Total_Area | 0.344 | 0.120 | 4.23E-03 | 4.93E-02 |
| Adlercreutzia | t_Total_Area | 0.378 | 0.132 | 4.22E-03 | 4.93E-02 |
| Bone Strength Measures | |||||
| DTU089 | r_fail_load_FEA | -0.543 | 0.172 | 1.60E-03 | 3.90E-02 |
| Flavonifractor | t_fail_load_FEA | -0.368 | 0.122 | 2.70E-03 | 4.57E-02 |
| Eggerthella | t_fail_load_FEA | -0.432 | 0.144 | 2.83E-03 | 4.59E-02 |
| Turicibacter | t_fail_load_FEA | 0.496 | 0.166 | 2.85E-03 | 4.59E-02 |
Bone measures were collected using high resolution peripheral quantitative computed tomography. Taxa-bone associations with Benjamini & Hochberg false discovery rate (FDR) adjusted P-value (Q-value) ≤ 0.05 are shown. Skeletal phenotypes are grouped according to whether they were measured in cortical bone, trabecular bone, whole bone, or overall measures of skeletal strength. All associations were adjusted for covariates.